Surfactant protein-D (SP-D) gene polymorphisms and serum level as predictors of susceptibility and prognosis of acute kidney injury in the Chinese population

BMC Nephrology

Research Article

Lianghai Li¹  Guang Li²  Jiao Liu²  Qingshan Zhou²  Dechang Chen³  Zhiyong Liu⁴  Guirong Wang⁵ 

[1] Department of Critical Care Medicine, Jingzhou Central Hospital, 434020, Jingzhou, Hubei, China;Department of Critical Care Medicine, Renmin Hospital of Wuhan University, 430060, Wuhan, Hubei, China;Department of Critical Care Medicine, Shanghai Ruijin Hospital Affiliated with Jiaotong University, Shanghai, China;Department of Internal medicine, Renmin Hospital of Wuhan University, 430060, Wuhan, Hubei, China;Department of Surgery, SUNY Upstate Medical University, 13210, Syracuse, NY, USA;

关键词: Acute kidney injury;    Surfactant protein D;    Polymorphism;    Kidney injury molecule-1;    Susceptibility;    Prognosis;   

DOI  :  10.1186/s12882-017-0485-x

 received in 2016-10-19, accepted in 2017-02-09,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundInjury to the kidney epithelial barrier is a characteristic feature of acute kidney injury (AKI). Serum surfactant protein-D (SP-D), a known biomarker of damaged alveolar epithelium, is also secreted by renal tubular epithelial cells. Therefore, the aim of this study was to examine the possible association of SP-D with AKI susceptibility and prognosis.MethodsIn this study, 159 AKI patients and 120 healthy individuals were included. SP-D polymorphisms Thr11Met and Thr160Ala, AKI patient serum SP-D levels at days 1, 3 and 7 and urine KIM-1 levels in both AKI patients and controls were examined. The obtained results were correlated with the AKI stage, duration of renal replacement therapy (RRT) and prognosis.ResultsSerum SP-D level in AKI patients was higher than controls (p < 0.01). SP-D 11Thr/Thr genotype was more frequent in AKI patients than in controls (p < 0.01). Furthermore, AKI patients with SP-D 11Thr/Thr genotype had significantly higher serum SP-D levels (p < 0.05) compared to other genotypes. Serum SP-D levels corrected to the progression of AKI with a peak at day 3. Furthermore, the SP-D 11Thr/Thr genotype frequency and baseline serum SP-D level were higher in patients who subsequently died. Baseline serum SP-D levels positively correlated with the urine KIM-1 levels, AKI stage and RRT duration.ConclusionIn our study, elevated serum SP-D was associated with worse AKI clinical outcomes and patients with SP-D 11Thr/Thr genotype were more susceptible to AKI. Collectively, these findings suggest that SP-D may be useful as a biomarker of AKI susceptibility and prognosis.

【 授权许可】

CC BY   
© The Author(s). 2017