Meta-analysis of the diagnostic performance of stress perfusion cardiovascular magnetic resonance for detection of coronary artery disease

Journal of Cardiovascular Magnetic Resonance

Research

Guillaume Née¹  Javed Ehtisham²  Martial Hamon³  Georges Fau⁴  Michèle Hamon⁵  Rémy Morello⁶ 

[1] CNRS UMR 6072, Greyc Laboratory, Caen, France;Department of Cardiology, University Hospital of Caen, France;Department of Cardiology, University Hospital of Caen, France;INSERM 744, Institut Pasteur de Lille, France;Department of Radiology, University Hospital of Caen, France;Department of Radiology, University Hospital of Caen, France;INSERM 919, Cyceron, Caen, France;Department of Statistics, University Hospital of Caen, France;

关键词: Cardiovascular Magnetic Resonance;    Leave Anterior Descend;    Late Gadolinium Enhancement;    Dipyridamole;    Right Coronary Artery;   

DOI  :  10.1186/1532-429X-12-29

 received in 2009-09-18, accepted in 2010-05-19,  发布年份 2010

来源: Springer

【 摘 要 】

AimEvaluation of the diagnostic accuracy of stress perfusion cardiovascular magnetic resonance for the diagnosis of significant obstructive coronary artery disease (CAD) through meta-analysis of the available data.MethodologyOriginal articles in any language published before July 2009 were selected from available databases (MEDLINE, Cochrane Library and BioMedCentral) using the combined search terms of magnetic resonance, perfusion, and coronary angiography; with the exploded term coronary artery disease. Statistical analysis was only performed on studies that: (1) used a [greater than or equal to] 1.5 Tesla MR scanner; (2) employed invasive coronary angiography as the reference standard for diagnosing significant obstructive CAD, defined as a [greater than or equal to] 50% diameter stenosis; and (3) provided sufficient data to permit analysis.ResultsFrom the 263 citations identified, 55 relevant original articles were selected. Only 35 fulfilled all of the inclusion criteria, and of these 26 presented data on patient-based analysis. The overall patient-based analysis demonstrated a sensitivity of 89% (95% CI: 88-91%), and a specificity of 80% (95% CI: 78-83%). Adenosine stress perfusion CMR had better sensitivity than with dipyridamole (90% (88-92%) versus 86% (80-90%), P = 0.022), and a tendency to a better specificity (81% (78-84%) versus 77% (71-82%), P = 0.065).ConclusionStress perfusion CMR is highly sensitive for detection of CAD but its specificity remains moderate.

【 授权许可】

CC BY   
© Hamon et al; licensee BioMed Central Ltd. 2010