Association of maternal serum concentrations of 2,2', 4,4'5,5'-hexachlorobiphenyl (CB-153) and 1,1-dichloro-2,2-bis (p-chlorophenyl)-ethylene (p,p'-DDE) levels with birth weight, gestational age and preterm births in Inuit and European populations

Environmental Health

Research

Henning S Pedersen¹  Katarzyna Góralczyk²  Jan K Ludwicki²  Jens Peter Bonde³  Gunnar Toft³  Bogdan J Wojtyniak⁴  Daniel Rabczenko⁴  Lars Rylander⁵  Lars Hagmar⁵  Bo AG Jönsson⁵  Valentyna Zvezday⁶  Anna Lesovaya⁶ 

[1] Centre for Arctic Environmental Medicine, Nuuk, Greenland;Department of Environmental Toxicology, National Institute of Public Health - National Institute of Hygiene, Warsaw, Poland;Department of Occupational Medicine, Aarhus University Hospital, Aarhus, Denmark;Department-Centre of Monitoring and Analyses of Population Health, National Institute of Public Health - National Institute of Hygiene, Warsaw, Poland;Division of Occupational and Environmental Medicine, Lund University, Lund, Sweden;Laboratory of Human Reproduction, Kharkiv State Medical University, Kharkiv, Ukraine;

关键词: Birth Weight;    Preterm Birth;    Maternal Serum;    Premature Birth;    Singleton Live Birth;   

DOI  :  10.1186/1476-069X-9-56

 received in 2009-11-25, accepted in 2010-09-06,  发布年份 2010

来源: Springer

【 摘 要 】

BackgroundEpidemiological studies on the association between maternal exposure to persistent organic pollutants (POPs) and fetal growth alteration report inconsistent findings which weights in favor of additional studies.MethodsBlood samples were collected from interviewed pregnant women in Greenland (572), Kharkiv (611) and Warsaw (258) and were analyzed for CB-153 and p,p'-DDE by gas chromatography-mass spectrometry. Data on birth weight, gestational age and preterm birth were obtained for 1322 singleton live births. We examined the association between natural log-transformed serum POPs concentration and birth weight and gestational age using multiple linear regression and the association with prematurity using logistic regression controlling for potential confounding factors.ResultsThe median serum concentrations of CB-153 and p,p'-DDE were for Inuit mothers 105.6 and 298.9, for Kharkiv mothers 27.0 and 645.4 and for Warsaw mothers 10.7 and 365.2 ng/g lipids, respectively. Increase in CB-153 concentration by one unit on the log scale in Inuit mothers serum was associated with significant decrease in infant birth weight of -59 g and gestational age by -0.2 week. Decreases observed in the cohorts in Kharkiv (-10 g and -0.1 week) and in Warsaw (-49 g and -0.2 week) were not statistically significant. Increase in p,p'-DDE concentration by one unit on the log scale was associated with a statistically significant decrease in infant birth weight of -39.4 g and -104.3 g and shortening of gestational age of -0.2 week and -0.6 week in the Inuit and Warsaw cohorts, respectively. In the Kharkiv cohort decrease in birth weight (-30.5 g) was not significant, however a shortening of gestational age of -0.2 week per increase in p,p'-DDE concentration by one unit on the log scale was of the borderline significance. There was no significant association between CB-153 and p,p'-DDE concentrations and risk of preterm birth however, in all cohorts the odds ratio was above 1.ConclusionsIn utero exposure to POPs may reduce birth weight and gestational age of newborns however, new insights as to why results vary across studies were not apparent.

【 授权许可】

CC BY   
© Wojtyniak et al; licensee BioMed Central Ltd. 2010