Different subsets of tumor infiltrating lymphocytes correlate with NPC progression in different ways

Molecular Cancer

Research

Hao-Yuan Mo¹  Fang Qiu¹  Yi-Lan Zhang²  Jiang Li²  Li-Min Zheng²  Yi-Xin Zeng²  Chao-Nan Qian³ 

[1] Department of Nasopharyngeal Carcinoma, Sun Yat-sen University Cancer Center, 651 Dongfeng Road east, 510060, Guangzhou, PR China;State Key Laboratory of Oncology in Southern China, Sun Yat-sen University Cancer Center, 651 Dongfeng Road east, 510060, Guangzhou, PR China;Department of Experimental Research, Sun Yat-sen University Cancer Center, 651 Dongfeng Road east, 510060, Guangzhou, PR China;Department of Biotherapy, Sun Yat-sen University Cancer Center, 651 Dongfeng Road east, 510060, Guangzhou, PR China;State Key Laboratory of Oncology in Southern China, Sun Yat-sen University Cancer Center, 651 Dongfeng Road east, 510060, Guangzhou, PR China;Department of Nasopharyngeal Carcinoma, Sun Yat-sen University Cancer Center, 651 Dongfeng Road east, 510060, Guangzhou, PR China;

关键词: Overall Survival;    Treg Cell;    Tumor Infiltrate Lymphocyte;    Poor Overall Survival;    Good Overall Survival;   

DOI  :  10.1186/1476-4598-9-4

 received in 2009-09-14, accepted in 2010-01-10,  发布年份 2010

来源: Springer

【 摘 要 】

BackgroundIncreasing amounts of evidence indicate that tumor infiltrating lymphocytes (TIL) are correlated with the prognosis of cancer patients. This study focuses on the association between the densities of tumor infiltrating cytotoxic T lymphocytes (CTL), activated CTL, regulatory T lymphocytes (Treg) and Th17 lymphocytes, and the prognosis and clinicopathological features of nasopharyngeal carcinoma (NPC) patients.ResultsDouble immunohistochemical staining was performed in 106 biopsy specimens from newly diagnosed NPC patients. Prognostic values of infiltrating lymphocyte densities were evaluated by Kaplan-Meier analysis and Cox regression. The density of CD8+ TIL was positively correlated with lymph node metastasis, while the density of Foxp3+ TIL was negatively associated with T stage (P < 0.05). For survival evaluation, the density of Foxp3+ TIL or Foxp3+ TIL combined with GrB+ TIL together was associated with better overall survival (OS) and progression-free survival (PFS) (P < 0.01) in all patients and in the patients with late-stage diseases (Stages III and IV, P < 0.01). Meanwhile a low density of CD8+TIL or high ratio of FOXP3+TIL to CD8+TIL was correlated with better PFS in early stage patients (Stages I and II, P < 0.05). No significant association was found between IL-17+ TIL and clinicopathological characteristic or survival of NPC patients.ConclusionsOur study identifies for the first time the tumor infiltrating Foxp3+ TIL as an independent favorable factor in the prognosis of NPC patients, especially for the patients with late-stage diseases.

【 授权许可】

Unknown   
© Zhang et al; licensee BioMed Central Ltd. 2010. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.