Synergies between assisted reproduction technologies and functional genomics

Genetics Selection Evolution

Review

John L. Williams¹  Emanuele Capra²  Alessandra Stella²  Paolo Ajmone Marsan³  Paola Toschi⁴  Pasqualino Loi⁴  Pier A. Scapolo⁴  Federica Zacchini⁵  Grazyna Ptak⁶ 

[1] Davies Research Centre, School of Animal and Veterinary Sciences, University of Adelaide, 5371, Roseworthy, SA, Australia;Institute of Agricultural Biology and Biotechnology, National Research Council, 26900, Lodi, Italy;Istituto di Zootecnica, Università Cattolica del Sacro Cuore, Piacenza, Italy;Proteomic and Nutrigenomic Research Center - PRONUTRIGEN, Università Cattolica del Sacro Cuore, Piacenza, Italy;Laboratory of Embryology, Faculty of Veterinary Medicine, University of Teramo, Teramo, Italy;Laboratory of Embryology, Faculty of Veterinary Medicine, University of Teramo, Teramo, Italy;Institute of Genetics and Animal Breeding of the Polish Academy of Sciences, Postepu 36A, Jastrzębiec, 05-552, Magdalenka, Poland;Laboratory of Embryology, Faculty of Veterinary Medicine, University of Teramo, Teramo, Italy;Institute of Genetics and Animal Breeding of the Polish Academy of Sciences, Postepu 36A, Jastrzębiec, 05-552, Magdalenka, Poland;National Research Institute of Animal Production 1, Krakowska Street, 32-083, Balice n/Kraków, Poland;

关键词: Imprint Gene;    Cobalamin;    Blastocyst Stage;    Artificial Insemination;    Genome Editing;   

DOI  :  10.1186/s12711-016-0231-z

 received in 2016-02-29, accepted in 2016-07-15,  发布年份 2016

来源: Springer

【 摘 要 】

This review, is a synopsis of advanced reproductive technologies in farm animals, including the discussion of their limiting factors as revealed by the study of offspring derived from embryos produced in vitro and through cloning. These studies show that the problems of epigenetic mis-programming, which were reported in the initial stages of assisted reproduction, still persist. The importance of whole-genome analyses, including the methylome and transcriptome, in improving embryo biotechnologies in farm animals, are discussed. Genome editing approaches for the improvement of economically-relevant traits in farm animals are also described. Efficient farm animal embryo biotechnologies, including cloning and the most recent technologies such as genome editing, will effectively complement the latest strategies to accelerate genetic improvement of farm animals.

【 授权许可】

CC BY   
© The Author(s) 2016