Vascular and plaque imaging with ultrasmall superparamagnetic particles of iron oxide

Journal of Cardiovascular Magnetic Resonance

Review

Jennifer Richards¹  Shirjel R. Alam²  Peter Henriksen²  Colin Stirrat²  David E. Newby²  Scott I. K. Semple³  Saeed Mirsadraee⁴  George Tse⁵ 

[1] Centre for Cardiovascular Science, The University of Edinburgh, The Chancellor’s Building, Little France Crescent, EH16 5SA, Edinburgh, UK;Centre for Cardiovascular Science, The University of Edinburgh, The Chancellor’s Building, Little France Crescent, EH16 5SA, Edinburgh, UK;Department of Cardiology, Royal Infirmary of Edinburgh, EH16 5SA, Edinburgh, UK;Clinical Research Imaging Centre, University of Edinburgh, EH16 5SA, Edinburgh, UK;Clinical Research Imaging Centre, University of Edinburgh, EH16 5SA, Edinburgh, UK;Department of Radiology, Royal Infirmary of Edinburgh, EH16 5SA, Edinburgh, UK;MRC Centre for Inflammation Research, The University of Edinburgh, EH16 5SA, Edinburgh, UK;

关键词: USPIO;    Nanoparticles;    CMR;    Cardiovascular imaging;    Inflammation;    Macrophage;   

DOI  :  10.1186/s12968-015-0183-4

 received in 2014-11-20, accepted in 2015-08-16,  发布年份 2015

来源: Springer

【 摘 要 】

Cardiovascular Magnetic Resonance (CMR) has become a primary tool for non-invasive assessment of cardiovascular anatomy, pathology and function. Existing contrast agents have been utilised for the identification of infarction, fibrosis, perfusion deficits and for angiography. Novel ultrasmall superparamagnetic particles of iron oxide (USPIO) contrast agents that are taken up by inflammatory cells can detect cellular inflammation non-invasively using CMR, potentially aiding the diagnosis of inflammatory medical conditions, guiding their treatment and giving insight into their pathophysiology. In this review we describe the utilization of USPIO as a novel contrast agent in vascular disease.

【 授权许可】

CC BY   
© Alam et al. 2015