Role of disturbed fatty acids metabolism in the pathophysiology of diabetic erectile dysfunction

Lipids in Health and Disease

Research

Kamel Jamoussi¹  Mohamed Raâfet Ben Khedher²  Mohamed Hammami²  Samia Haj Ahmed²  Houda Bouhajja³  Mohamed Abid³ 

[1] Biochemistry Laboratory, University Hospital Hedi Chaker of Sfax, Sfax, Tunisia;Laboratory of Nutrition, Functional Food and Vascular Health, Department of Biochemistry, Faculty of Medicine, University of Monastir, Avenue Avicenne, 5019, Monastir, Tunisia;Unit of Obesity and Metabolic Syndrome, Department of Endocrinology, University Hospital Hedi Chaker of Sfax, Sfax, Tunisia;

关键词: Diabetic erectile dysfunction;    Fatty acids;    Inflammation;    Insulin resistance;    Type 2 diabetes;   

DOI  :  10.1186/s12944-017-0637-9

 received in 2017-08-28, accepted in 2017-12-05,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundVasculogenic erectile dysfunction (VED) is considered as a common complication among people with type 2 diabetes (T2D). We tested whether changes in fatty acid (FAs) classes measured in erythrocytes are associated with increased risk of diabetic VED along with related risk factors.MethodsWe assessed erythrocyte FAs composition, lipid peroxidation parameters and inflammatory cytokines among 72 T2D men with VED, 78 T2D men without VED and 88 healthy volunteers with similar age. Biochemical, hepatic, lipid and hormonal profiles were measured.ResultsT2D people with VED had significant decrease in the indexes of Δ6-desaturase and elongase activities compared to the other studied groups. The same group of participants displayed lower erythrocytes levels of dihomo-γ-linolenic acid (C20:3n-6) (P < .001), precursor of the messenger molecule PGE1 mainly involved in promoting erection. Moreover, absolute SFAs concentration and HOMA IR levels were higher in T2D people with VED when compared to controls and associated with impaired NO concentration (1.43 vs 3.30 ng/L, P < .001). Our results showed that IL-6 and TNF-α were significantly increased and positively correlated with MDA levels only in T2D people with VED (r = 0.884, P = .016 and r = 0.753, P = .035; respectively) suggesting a decrease in the relative availability of vasodilator mediators and an activation of vasoconstrictors release.ConclusionOur findings show that the deranged FAs metabolism represents a potential marker of VED in progress, or at least an indicator of increased risk within men with T2D.

【 授权许可】

CC BY   
© The Author(s). 2017