Effects of endogenous and exogenous micronutrients in rapeseed oils on the antioxidant status and lipid profile in high-fat fed rats

Lipids in Health and Disease

Research

Fangli Ma¹  Lan Wang²  Qianchun Deng³  Xiao Yu³  Qingde Huang³  Changsheng Liu³  Jiqu Xu³  Fenghong Huang³ 

[1] Functional Oil Laboratory Associated by Oil Crops Research Institute, Chinese Academy of Agricultural Sciences and Infinite (China) Co., LTD., 51000, Guangzhou, China;Institute for Farm Products Processing and Nuclear-Agricultural Technology, Hubei Academy of Agricultural Science, 430064, Wuhan, China;Oil Crops Research Institute, Chinese Academy of Agricultural Sciences, 2 Xudong Second Road, 430062, Wuhan, China;Hubei Key Laboratory of Lipid Chemistry and Nutrition, 430062, Wuhan, China;

关键词: Rapeseed oil;    Cold-pressed;    Tocopherols;    Phytosterols;    Antioxidant status;   

DOI  :  10.1186/1476-511X-13-198

 received in 2014-09-05, accepted in 2014-12-01,  发布年份 2014

来源: Springer

【 摘 要 】

BackgroundMicronutrients in oil reduce one or more risk factors of cardiovascular diseases, while the contents of micronutrients in oil are relatively poor, which is insufficient to reverse the metabolic disorders at different stages of progress. The aim of this study was to investigate the effects of endogenous micronutrients in optimized cold-pressed rapeseed oil and restoratively added or fortified micronutrients in traditional refined rapeseed oil (restoring micronutrients to be nearly equal to or significantly higher than levels in crude rapeseed oil) on the antioxidant status and lipid profile in high-fat fed rats.MethodsMale Wistar rats were fed high-fat diets containing different rapeseed oils for 4 weeks, including the standard refined rapeseed oil(SRO), optimized cold-pressed rapeseed oil(CRO) and the traditional refined rapeseed oil with restorative addition or fortification of micronutrients (LF, HF-SRO).ResultsCRO exhibited significant increases in contents of tocopherols (+13%), phytosterols (+34%), polyphenols (+92%) and phospholipids (+725%) compared with SRO, as well as the total antioxidant capacities (+82-125%) (p < 0.05). While the HF-SRO revealed improved antioxidant properties in vitro than the CRO, which was comparable to LF-SRO. Significant improved plasma antioxidant capacities and lipid peroxidation evaluated by T-AOC, GSH, tocopherols and MDA were found in rats fed HF-SRO when compared with CRO and LF-SRO (p < 0.05). Furthermore, HF-SRO also decreased the plasma and hepatic TC levels compared to CRO and LF-SRO, accompanying higher fecal cholesterol excretion (p < 0.05).ConclusionThe standard refined rapeseed oil with fortification, not restorative addition of micronutrients was comparable to the optimized cold-pressed rapeseed oil in improving the antioxidant status and lipid profile of high-fat fed rats.

【 授权许可】

Unknown   
© Deng et al.; licensee BioMed Central. 2014. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.