Left atrial structure and functional quantitation using cardiovascular magnetic resonance and multimodality tissue tracking: validation and reproducibility assessment

Journal of Cardiovascular Magnetic Resonance

Research

Mytra Zareian¹  Luisa Ciuffo¹  Mohammadali Habibi¹  Elzbieta H. Chamera¹  Bharath Ambale Venkatesh¹  João A. C. Lima¹  Colin O. Wu²  David A. Bluemke²  Anders Opdahl³ 

[1] MR 110, Radiology, Johns Hopkins University, 21287, Baltimore, MD, USA;National Institutes of Health, Bethesda, MD, USA;Oslo University Hospital and University of Oslo, Oslo, Norway;

关键词: Left atrial function;    Tissue tracking;    Left atrial strain;    Reproducibility;    Cardiovascular magnetic resonance;   

DOI  :  10.1186/s12968-015-0152-y

 received in 2015-01-03, accepted in 2015-06-09,  发布年份 2015

来源: Springer

【 摘 要 】

BackgroundLeft atrium (LA) strain, volume and function are important markers of cardiovascular disease and myocardial impairment. We aimed to assess the accuracy of LA biplane volume and function measured by Multimodality Tissue Tracking (MTT). Also we assessed the inter-study reproducibility for cardiovascular magnetic resonance (CMR) derived LA volume and function parameters.MethodsThirty subjects (mean age: 71.3 ± 8.7, 87 % male) including twenty subjects with cardiovascular events and ten healthy subjects, with CMR were evaluated in the Multi-Ethnic Study of Atherosclerosis (MESA). LA volumes were computed by the modified biplane method from 2- and 4-chamber projections and the Simpson’s method from short-axis slices using both methods - manual and semi-automated delineation using MTT. LA total, active and passive ejection fractions were calculated. Pearson’s correlation and Bland-Altman analysis were used to compare the measurements. In a second sample of 25 subjects (age: 65.7 ± 7.1, 72 % males) inter study, intra and inter reader reliability analysis was performed. The intra-class correlation coefficient (ICC) was evaluated.ResultsLeft atrial MTT structural and functional parameters were not different from manual delineation, yet image analysis was only half as time consuming on average with MTT. Maximal volume MTT was not different between the Simpson’s and Biplane methods, functional parameters, however were different. MTT allowed us to measure multiple LA parameters with good-excellent (ICC; 0.88– 0.98, p < 0.001) intra-and inter reader reproducibility and fair-good (ICC; 0.44–0.82, p < 0.05–0.001) inter study reproducibility.ConclusionsMTT derived LA biplane volume and function is accurate and reproducible and is suited for use in longitudinal studies.

【 授权许可】

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© Zareian et al. 2015. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.