BMC Genomics | |
Correlated mRNAs and miRNAs from co-expression and regulatory networks affect porcine muscle and finally meat properties | |
Research Article | |
Yang Du1  Eduard Murani1  Klaus Wimmers1  Puntita Siengdee2  Frieder Hadlich2  Manfred Schwerin2  Siriluck Ponsuksili2  | |
[1] Institute for Genome Biology, Leibniz Institute for Farm Animal Biology (FBN), Wilhelm-Stahl-Allee 2, D-18196, Dummerstorf, Germany;Research Group ‘Functional Genome Analyses, Leibniz Institute for Farm Animal Biology (FBN), Wilhelm-Stahl-Allee 2, D-18196, Dummerstorf, Germany; | |
关键词: Gene Ontology; Meat Quality; miRNA Family; Carcass Trait; Drip Loss; | |
DOI : 10.1186/1471-2164-14-533 | |
received in 2012-12-17, accepted in 2013-07-30, 发布年份 2013 | |
来源: Springer | |
【 摘 要 】
BackgroundPhysiological processes aiding the conversion of muscle to meat involve many genes associated with muscle structure and metabolic processes. MicroRNAs regulate networks of genes to orchestrate cellular functions, in turn regulating phenotypes.ResultsWe applied weighted gene co-expression network analysis to identify co-expression modules that correlated to meat quality phenotypes and were highly enriched for genes involved in glucose metabolism, response to wounding, mitochondrial ribosome, mitochondrion, and extracellular matrix. Negative correlation of miRNA with mRNA and target prediction were used to select transcripts out of the modules of trait-associated mRNAs to further identify those genes that are correlated with post mortem traits.ConclusionsPorcine muscle co-expression transcript networks that correlated to post mortem traits were identified. The integration of miRNA and mRNA expression analyses, as well as network analysis, enabled us to interpret the differentially-regulated genes from a systems perspective. Linking co-expression networks of transcripts and hierarchically organized pairs of miRNAs and mRNAs to meat properties yields new insight into several biological pathways underlying phenotype differences. These pathways may also be diagnostic for many myopathies, which are accompanied by deficient nutrient and oxygen supply of muscle fibers.
【 授权许可】
Unknown
© Ponsuksili et al.; licensee BioMed Central Ltd. 2013. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
【 预 览 】
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