Metal nanoparticles: understanding the mechanisms behind antibacterial activity

Journal of Nanobiotechnology

Review

Yael N. Slavin¹  Horacio Bach¹  Urs O. Häfeli²  Jason Asnis² 

[1] Department of Medicine, Division of Infectious Diseases, University of British Columbia, 410-2660 Oak St., V6H3Z6, Vancouver, BC, Canada;Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, BC, Canada;

关键词: Nanoparticles;    Metals;    ROS;    Mechanism of defense;    Bacteria;    Transcriptomics;    Proteomics;    Gene regulation;    Antibacterial resistance;   

DOI  :  10.1186/s12951-017-0308-z

 received in 2017-07-03, accepted in 2017-09-25,  发布年份 2017

来源: Springer

【 摘 要 】

As the field of nanomedicine emerges, there is a lag in research surrounding the topic of nanoparticle (NP) toxicity, particularly concerned with mechanisms of action. The continuous emergence of bacterial resistance has challenged the research community to develop novel antibiotic agents. Metal NPs are among the most promising of these because show strong antibacterial activity. This review summarizes and discusses proposed mechanisms of antibacterial action of different metal NPs. These mechanisms of bacterial killing include the production of reactive oxygen species, cation release, biomolecule damages, ATP depletion, and membrane interaction. Finally, a comprehensive analysis of the effects of NPs on the regulation of genes and proteins (transcriptomic and proteomic) profiles is discussed.

【 授权许可】

CC BY   
© The Author(s) 2017