Escape from IFN-γ-dependent immunosurveillance in tumorigenesis

Journal of Biomedical Science

Review

Szu-Yuan Wu¹  Tsung-Ting Tsai²  Po-Chun Tseng²  Yu-Chih Wang²  Chiou-Feng Lin³  Chih-Ming Lin⁴  Po-Hao Feng⁵  Kang-Yun Lee⁵  Kuan-Yuan Chen⁶  Hsiao-Chi Chuang⁷  Chia-Ling Chen⁸ 

[1] Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, 110, Taipei, Taiwan;Graduate Institute of Toxicology, College of Medicine, National Taiwan University, 100, Taipei, Taiwan;Department of Radiation Oncology, Wan Fang Hospital, Taipei Medical University, Taipei Medical University, 110, Taipei, Taiwan;Department of Biotechnology, Hung Kuang University, 433, Taichung, Taiwan;Department of Microbiology and Immunology, School of Medicine, College of Medicine, Taipei Medical University, 110, Taipei, Taiwan;Department of Microbiology and Immunology, School of Medicine, College of Medicine, Taipei Medical University, 110, Taipei, Taiwan;Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, 110, Taipei, Taiwan;Department of Thoracic Surgery, Lotung Poh-Ai Hospital, 265, Yilan, Taiwan;Division of Pulmonary Medicine, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, 110, Taipei, Taiwan;Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, 110, Taipei, Taiwan;Division of Pulmonary Medicine, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, 110, Taipei, Taiwan;Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, 110, Taipei, Taiwan;Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, 110, Taipei, Taiwan;School of Respiratory Therapy, College of Medicine, Taipei Medical University, 110, Taipei, Taiwan;Translational Research Center, Taipei Medical University, 110, Taipei, Taiwan;

关键词: Cancer;    Immunosurveillance;    IFN-γ;    Hyporesponsiveness;    Escape;   

DOI  :  10.1186/s12929-017-0317-0

 received in 2016-09-30, accepted in 2017-01-19,  发布年份 2017

来源: Springer

【 摘 要 】

Immune interferon (IFN), also known as IFN-γ, promotes not only immunomodulation but also antimicrobial and anticancer activity. After IFN-γ binds to the complex of IFN-γ receptor (IFNGR) 1-IFNGR2 and subsequently activates its downstream signaling pathways, IFN-γ immediately causes transcriptional stimulation of a variety of genes that are principally involved in its biological activities. Regarding IFN-γ-dependent immunosurveillance, IFN-γ can directly suppress tumorigenesis and infection and/or can modulate the immunological status in both cancer cells and infected cells. Regarding the anticancer effects of IFN-γ, cancer cells develop strategies to escape from IFN-γ-dependent cancer immunosurveillance. Immune evasion, including the recruitment of immunosuppressive cells, secretion of immunosuppressive factors, and suppression of cytotoxic T lymphocyte responses, is speculated to be elicited by the oncogenic microenvironment. All of these events effectively downregulate IFN-γ-expressing cells and IFN-γ production. In addition to these extrinsic pathways, cancer cells may develop cellular tolerance that manifests as hyporesponsiveness to IFN-γ stimulation. This review discusses the potential escape mechanisms from IFN-γ-dependent immunosurveillance in tumorigenesis.

【 授权许可】

CC BY   
© The Author(s). 2017