Predictive factors of urinary tract infections among the oldest old in the general population. a population-based prospective follow-up study

BMC Medicine

Research Article

Wendy PJ den Elzen¹  Jacobijn Gussekloo¹  Herman JM Cools¹  Monique AA Caljouw¹ 

[1] Department of Public Health and Primary Care, Leiden University Medical Center, The Netherlands;

关键词: Urinary Tract Infection;    Benign Prostatic Hyperplasia;    International Prostate Symptom Score;    Bacteriuria;    Recurrent Urinary Tract Infection;   

DOI  :  10.1186/1741-7015-9-57

 received in 2011-01-17, accepted in 2011-05-16,  发布年份 2011

来源: Springer

【 摘 要 】

BackgroundUrinary tract infections (UTI) are common among the oldest old and may lead to a few days of illness, delirium or even to death. We studied the incidence and predictive factors of UTI among the oldest old in the general population.MethodsThe Leiden 85-plus Study is a population-based prospective follow-up study of 86-year-old subjects in Leiden, The Netherlands. Information on the diagnosis of UTI was obtained annually during four years of follow-up from the medical records and interviews of treating physicians. A total of 157 men and 322 women aged 86 years participated in the study. Possible predictive factors were collected at baseline, including history of UTI between the age of 85 and 86 years, aspects of functioning (cognitive impairment (Mini-Mental State Examination (MMSE) < 19), presence of depressive symptoms (Geriatric Depression Scale (GDS) > 4), disability in activities of daily living (ADL)), and co-morbidities.ResultsThe incidence of UTI from age 86 through 90 years was 11.2 (95% confidence interval (CI) 9.4, 13.1) per 100 person-years at risk. Multivariate analysis showed that history of UTI between the age of 85 and 86 years (hazard ratio (HR) 3.4 (95% CI 2.4, 5.0)), impaired cognitive function (HR 1.9 (95% CI 1.3, 2.9)), disability in daily living (HR 1.7 (95% CI 1.1, 2.5)) and urine incontinence (HR 1.5 (95% CI 1.0, 2.1)) were independent predictors of an increased incidence of UTI from age 86 onwards.ConclusionsWithin the oldest old, a history of UTI between the age of 85 and 86 years, cognitive impairment, ADL disability and urine incontinence are independent predictors of developing UTI. These predictive factors could be used to target preventive measures to the oldest old at high risk of UTI.

【 授权许可】

CC BY   
© Caljouw et al; licensee BioMed Central Ltd. 2011