Inflammatory Wnt5A signalling pathways affecting barrier function of human vascular endothelial cells

Journal of Inflammation

Commentary

Tom Skaria¹  Gabriele Schoedon¹ 

[1] Inflammation Research Unit, Division of Internal Medicine, University Hospital Zürich, Rämistrasse 100, CH-8091, Zürich, Switzerland;

关键词: Inflammation;    Wnt5A;    Endothelial barrier function;    Ryk;    IL-4;    Wnt inhibitory factor-1;   

DOI  :  10.1186/s12950-017-0163-6

 received in 2017-06-19, accepted in 2017-07-05,  发布年份 2017

来源: Springer

【 摘 要 】

Wnt5A is a chemokine secreted by inflammatory-activated human macrophages that sustains their inflammatory response in an autocrine manner. High levels of Wnt5A are found in sera of patients with sepsis and septic shock.Here, we comment on recently reported Wnt5A signalling pathways in human vascular endothelial cells (VEC). In human VEC, Wnt5A regulates cytoskeleton remodelling and barrier function through Ryk receptor and Rho-associated protein serine/threonine kinase, targeting LIMK2 and CFL1 involved in actin polymerisation. Wnt5A/Ryk signalling in VEC can be antagonised by the naturally occurring Wnt inhibitory factor (WIF)-1 (WIF1).Therapeutic targeting of this mechanism may reduce vascular leakage and edema in severe systemic inflammation and therefore should be subject of further investigations.

【 授权许可】

CC BY   
© The Author(s). 2017