The G-Protein β3 subunit 825 TT genotype is associated with epigastric pain syndrome-like dyspepsia

BMC Medical Genetics

Research Article

Tetsuji Yokoyama¹  Shigemi Nakajima²  Takayuki Matsumoto³  Junji Tanaka⁴  Toshihiko Tomita⁴  Kazutoshi Hori⁴  Fumihiko Toyoshima⁴  Jun Sakurai⁴  Yongmin Kim⁴  Hiroto Miwa⁴  Tadayuki Oshima⁴ 

[1] Department of Human Resources Development, National Institute of Public Health, 351-0197, Wako, Japan;Department of Medicine, Healthcare Social Insurance Shiga Hospital, 520-0846, Otsu, Japan;Divisions of Lower Gastroenterology, Department of Internal Medicine, Hyogo College of Medicine, 663-8501, Nishinomiya, Japan;Divisions of Upper Gastroenterology, Department of Internal Medicine, Hyogo College of Medicine, 663-8501, Nishinomiya, Japan;

关键词: Irritable Bowel Syndrome;    Dyspepsia;    Functional Dyspepsia;    Dyspeptic Symptom;    825T Allele;   

DOI  :  10.1186/1471-2350-11-13

 received in 2009-09-22, accepted in 2010-01-26,  发布年份 2010

来源: Springer

【 摘 要 】

BackgroundAlthough familial clustering of functional dyspepsia (FD) has been reported, the role of genetics in the susceptibility to FD is still not well understood. Several reports indicate an association between FD and G-protein β3 (GNB3) subunit gene polymorphism (C825T); however, these studies had small sample sizes and the findings are inconclusive. In the present study we clarified the association between GNB3 gene polymorphism and dyspepsia in a large population of Japanese subjects who visited a hospital for annual health check-up.MethodsSubjects with significant upper gastrointestinal findings were excluded. Subjects with dyspeptic symptoms were divided into either a postprandial distress syndrome (PDS) group or an epigastric pain syndrome (EPS) group according to the Rome III criteria. The presence of the GNB3 C825T polymorphism was then evaluated and logistic regression analysis was used to test all variables.ResultsThe GNB3 genotype distribution in subjects without dyspepsia was 191 CC (25.1%), 368 TC (48.4%), and 202 TT (26.5%) and 17 CC (25.0%), 29 TC (42.6%), and 22 TT (32.4%) in subjects with dyspepsia. No significant correlation was found between the GNB3 825TT genotype and dyspepsia. However, the TT genotype was significantly associated with subjects with EPS-like symptoms (odds ratio (OR) = 2.00, 95% confidence interval (CI); 1.07-3.76) compared to the CT/CC genotype adjusted for gender and age. No significant correlation was found between GNB3 polymorphism and PDS-like symptoms (OR = 0.68, 95% CI; 0.31-1.51). With the exclusion of subjects with both EPS- and PDS-like symptoms, only the TT genotype was significantly associated with EPS-like symptoms (OR = 2.73, 95% CI; 1.23-5.91).ConclusionThe homozygous GNB3 825T allele influences the susceptibility to EPS-like dyspepsia.

【 授权许可】

Unknown   
© Oshima et al; licensee BioMed Central Ltd. 2010. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.