Performance of “VIKIA Malaria Ag Pf/Pan” (IMACCESS®), a new malaria rapid diagnostic test for detection of symptomatic malaria infections

Malaria Journal

Research

Monidarin Chou¹  Sophy Chy²  Dany Dourng²  Didier Ménard²  Sarorn Sum²  Nimol Khim²  Saorin Kim²  Lydie Canier²  Chea Nguon³ 

[1] Faculty of Pharmacy, Université des Sciences de la Santé, Phnom Penh, Cambodia;Malaria Molecular Epidemiology Unit, Institut Pasteur du Cambodge, Phnom Penh, Cambodia;National Center for Parasitology, Entomology and Malaria Control, Phnom Penh, Cambodia;

关键词: Malaria;    Plasmodium;    Falciparum Malaria;    Rapid Diagnostic Test;    Parasite Density;   

DOI  :  10.1186/1475-2875-11-295

 received in 2012-06-30, accepted in 2012-08-15,  发布年份 2012

来源: Springer

【 摘 要 】

BackgroundRecently, IMACCESS® developed a new malaria test (VIKIA Malaria Ag Pf/Pan™), based on the detection of falciparum malaria (HRP-2) and non-falciparum malaria (aldolase).MethodsThe performance of this new malaria rapid diagnostic test (RDT) was assessed using 1,000 febrile patients seeking malaria treatment in four health centres in Cambodia from August to December 2011. The results of the VIKIA Malaria Ag Pf/Pan were compared with those obtained by microscopy, the CareStart Malaria™ RDT (AccessBio®) which is currently used in Cambodia, and real-time PCR (as “gold standard”).ResultsThe best performances of the VIKIA Malaria Ag Pf/Pan™ test for detection of both Plasmodium falciparum and non-P. falciparum were with 20–30 min reading times (sensitivity of 93.4% for P. falciparum and 82.8% for non-P. falciparum and specificity of 98.6% for P. falciparum and 98.9% for non-P. falciparum) and were similar to those for the CareStart Malaria™ test.ConclusionsThis new RDT performs similarly well as other commercially available tests (especially the CareStart Malaria™ test, used as comparator), and conforms to the World Health Organization’s recommendations for RDT performance. It is a good alternative tool for the diagnosis of malaria in endemic areas.

【 授权许可】

Unknown   
© Chou et al.; licensee BioMed Central Ltd. 2012. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.