LC3B globular structures correlate with survival in esophageal adenocarcinoma

BMC Cancer

Research Article

Seamus O’Reilly¹  Elaine W. Kay²  Anthony O’Grady²  Mary-Clare Cathcart³  John Reynolds³  Jacintha O’Sullivan³  Tracey R. O’Donovan⁴  Gerald C. O’Sullivan⁴  Sharon L. McKenna⁴  Shereen El-Mashed⁴  Ayat R. Abdallah⁵ 

[1] Department of Oncology, Cork University Hospital, Cork, Ireland;Department of Pathology, Royal College of Surgeons Ireland (RCSI), Beaumont Hospital, Dublin, Ireland;Department of Surgery & Trinity Centre for Health Sciences, St James Hospital, Dublin, Ireland;Leslie C. Quick Laboratory, Cork Cancer Research Centre, BioSciences Institute, University College, Cork, Ireland;National Liver Institute, Menoufiya University, Shebin El Kom, Egypt;

关键词: Esophageal Adenocarcinoma;    Tumor Section;    Globular Structure;    Urothelial Cell Carcinoma;    KYSE450 Cell;   

DOI  :  10.1186/s12885-015-1574-5

 received in 2015-05-08, accepted in 2015-07-27,  发布年份 2015

来源: Springer

【 摘 要 】

BackgroundEsophageal adenocarcinoma has the fastest growing incidence of any solid tumor in the Western world. Prognosis remains poor with overall five-year survival rates under 25 %. Only a limited number of patients benefit from chemotherapy and there are no biomarkers that can predict outcome. Previous studies have indicated that induction of autophagy can influence various aspects of tumor cell biology, including chemosensitivity. The objective of this study was to assess whether expression of the autophagy marker (LC3B) correlated with patient outcome.MethodsEsophageal adenocarcinoma tumor tissue from two independent sites, was examined retrospectively. Tumors from 104 neoadjuvant naïve patients and 48 patients post neoadjuvant therapy were assembled into tissue microarrays prior to immunohistochemical analysis. Kaplan-Meier survival curves and log-rank tests were used to assess impact of LC3B expression on survival. Cox regression was used to examine association with clinical risk factors.ResultsA distinct globular pattern of LC3B expression was found to be predictive of outcome in both patient groups, irrespective of treatment (p < 0.001). Multivariate analysis found that this was a strong independent predictor of poor prognosis (p < 0.001).ConclusionsThis distinctive staining pattern of LC3B represents a novel prognostic marker for resectable esophageal adenocarcinoma.

【 授权许可】

CC BY   
© El-Mashed et al. 2015