Effects of gadolinium contrast agent on aortic blood flow and myocardial strain measurements by phase-contrast cardiovascular magnetic resonance

Journal of Cardiovascular Magnetic Resonance

Research

Erik Hedström¹  Håkan Arheden¹  Erik Bergvall¹  Freddy Ståhlberg²  Karin Markenroth Bloch³ 

[1] Department of Clinical Physiology, Lund University, Lund, Sweden;Department of Medical Radiation Physics, Lund University, Lund, Sweden;Department of Radiology, Lund University, Lund, Sweden;Philips Medical Systems, Best, the Netherlands;Department of Imaging and Function, Skåne University Hospital, Lund, Sweden;

关键词: Contrast Agent;    Aortic Flow;    Magnitude Image;    Contrast Agent Administration;    Quantitative Flow;   

DOI  :  10.1186/1532-429X-12-70

 received in 2010-08-19, accepted in 2010-11-24,  发布年份 2010

来源: Springer

【 摘 要 】

BackgroundQuantitative blood flow and aspects of regional myocardial function such as myocardial displacement and strain can be measured using phase-contrast cardiovascular magnetic resonance (PC-CMR). Since a gadolinium-based contrast agent is often used to measure myocardial infarct size, we sought to determine whether the contrast agent affects measurements of aortic flow and myocardial displacement and strain. Phase-contrast data pre and post contrast agent was acquired during free breathing using 1.5T PC-CMR.ResultsFor aortic flow and regional myocardial function 12 and 17 patients were analysed, respectively. The difference pre and post contrast agent was 0.03 ± 0.16 l/min for cardiac output, and 0.1 ± 0.5 mm for myocardial displacement. Linear regression for myocardial displacement (MD) after and before contrast agent (CA) showed MDpostCA = 0.95MDpreCA+0.05 (r = 0.95, p < 0.001). For regional myocardial function, the contrast-to-noise ratios for left ventricular myocardial wall versus left ventricular lumen were pre and post contrast agent administration 7.4 ± 3.3 and 4.4 ± 8.9, respectively (p < 0.001). The contrast-to-noise ratios for left ventricular myocardial wall versus surrounding tissue were pre and post contrast agent administration -16.9 ± 22 and -0.2 ± 6.3, respectively (p < 0.0001).ConclusionsQuantitative measurements of aortic flow yield equal results both in the absence and presence of gadolinium contrast agent. The total examination time may thereby be reduced when assessing both viability and quantitative flow using PC-CMR, by assessing aortic flow post contrast agent administration. Phase-contrast information for myocardial displacement is also assessable both in the absence and presence of contrast agent. However, delineation of the myocardium may be difficult or impossible post contrast agent due to the lower image contrast. Acquisition of myocardial displacement should therefore be performed pre contrast agent using current PC-CMR sequences.

【 授权许可】

Unknown   
© Hedström et al; licensee BioMed Central Ltd. 2010. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.