The diagnostic value of iron oxide nanoparticles for imaging of myocardial inflammation – quo vadis?

Journal of Cardiovascular Magnetic Resonance

Review

Anca Florian¹  Michael Bietenbeck¹  Ali Yilmaz¹  Udo Sechtem² 

[1] Department of Cardiology and Angiology, Albert-Schweitzer-Campus 1, building A1, 48149, Münster, Germany;Division of Cardiology, Robert-Bosch-Krankenhaus, Stuttgart, Germany;

关键词: Cardiovascular magnetic resonance;    SPIO;    Myocardial;    Inflammation;    Infarction;    Monocytes;   

DOI  :  10.1186/s12968-015-0165-6

 received in 2015-03-06, accepted in 2015-06-24,  发布年份 2015

来源: Springer

【 摘 要 】

Cardiovascular magnetic resonance (CMR) is an integral part in the diagnostic work-up of cardiac inflammatory diseases. In this context, superparamagnetic iron oxide-based contrast agents can provide additional diagnostic information regarding the assessment of myocardial infarction and myocarditis. After intravenous administration, these nanoparticles are taken up by activated monocytes and macrophages, which predominantly accumulate in regions associated with inflammation as was successfully shown in recent preclinical studies. Furthermore, first clinical studies with a new iron oxide-complex that was clinically approved for the treatment of iron deficiency anaemia recently demonstrated a superior diagnostic value of iron oxide nanoparticles compared to gadolinium-based compounds for imaging of myocardial inflammation in patients with acute myocardial infarction. In this article, we outline the basic features of superparamagnetic iron oxide-based contrast agents and review recent studies using such nanoparticles for cardiac imaging in case of acute myocardial infarction as well as acute myocarditis. Moreover, we highlight the translational potential of these agents and possible research applications with regard to imaging and therapy.

【 授权许可】

Unknown   
© Bietenbeck et al. 2015. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.