Effects of nutritional intake on disease severity in children with sickle cell disease

Nutrition Journal

Research

Giovanni Palazzi¹  Elena Bigi²  Valentina Mandese³  Luca Bedetti³  Francesca Marotti³  Lorenzo Iughetti⁴ 

[1] Oncology and Hematology Pediatric Unit, Department for Maternal and Child Integrated Activities, University Hospital of Modena, 41124, Modena, Italy;Pediatric Unit, Department of Medical and Surgical Sciences for Mothers, Children and Adults, University of Modena and Reggio Emilia, Via del Pozzo 71, 41124, Modena, Italy;School of Pediatrics, Department of Medical and Surgical Sciences for Mothers, Children and Adults, University of Modena and Reggio Emilia, 41124, Modena, Italy;School of Pediatrics, Department of Medical and Surgical Sciences for Mothers, Children and Adults, University of Modena and Reggio Emilia, 41124, Modena, Italy;Department of Medical and Surgical Sciences for Mothers, Children and Adults, University of Modena, and Reggio Emilia, Via del Pozzo 71, 41124, Modena, Italy;

关键词: Diet;    Macronutrient;    Micronutrient;    Nutritional intake;    Disease severity;    Sickle cell disease;   

DOI  :  10.1186/s12937-016-0159-8

 received in 2015-12-02, accepted in 2016-04-14,  发布年份 2016

来源: Springer

【 摘 要 】

BackgroundChildren with Sickle Cell Disease (SCD) may show growth failure in comparison to healthy peers. Many factors as hematological status, endocrine and/or metabolic dysfunction, and nutritional status, may play an important role in growth failure. The aim of this study was to assess whether impaired growth and nutritional intake can affect SCD severity during childhood.MethodsWe conducted an observational study on children with SCD referring to our clinic for routine follow-up visits in a 6-month period. We collected information on weight, height and body mass index (BMI) and calculated their respective standardized scores (z). The nutritional intake was assessed through the last 24-h recall intake of total calories, macro- (proteins, lipids, carbohydrates) and micronutrients (calcium, iron, phosphorus, vitamins B1, PP, A, C, B2). Disease severity was assessed through total hemoglobin (Hb) and fetal hemoglobin (HbF), and lactic dehydrogenase (LDH) levels, and through the total number and days of hospitalizations, as well as the lifetime episodes of acute chest syndrome (ACS).ResultsTwenty nine children (14 males, 15 females) with SCD were enrolled; their mean age was 9.95 years (SD 3.50, min 3.72, max 17.18). Z-weight and z-BMI were significantly directly related to total Hb. Food intake resulted significantly unbalanced in terms of total calorie intake, macro- and micronutrients, especially calcium, iron, vitamin B1 and C. Low intake of calcium and vitamin B1 were significantly inversely correlated with number and days of hospitalizations per year. Protein, lipid, phosphorus, and vitamin PP intakes resulted adequate but were inversely correlated with number and days of hospitalizations. Carbohydrate, lipid, iron, phosphorus, vitamins B1 and B2 intakes were significantly inversely correlated to HbF levels.ConclusionsThis study showed that, in our population, inadequate nutritional intake, weight and BMI have a significant impact on SCD severity indices.

【 授权许可】

CC BY   
© Mandese et al. 2016