Early fever in patients with primary intracerebral hemorrhage is associated with worse long-term functional outcomes: a prospective study

BMC Neurology

Research

Yi-Hsiang Chiu¹  Yun-Chang Chen¹  Ming-Yen Hsiao²  Wen-Che Tseng³  Hsin-Shui Chen³ 

[1] Department of Physical Medicine and Rehabilitation, National Taiwan University Hospital, 7, Zhongshan S. Rd, Taipei, Taiwan;Department of Physical Medicine and Rehabilitation, National Taiwan University Hospital, 7, Zhongshan S. Rd, Taipei, Taiwan;Department of Physical Medicine and Rehabilitation, College of Medicine, National Taiwan University, 7, Zhongshan S. Rd, Taipei, Taiwan;Department of Physical Medicine and Rehabilitation, National Taiwan University Hospital, Yunlin Branch, 579, Sec. 2, Yunlin Rd, Douliu City, Yunlin County, Taiwan;

关键词: Intracerebral hemorrhage˙functional outcome˙prognosis˙survivors ˙ fever;   

DOI  :  10.1186/s12883-023-03426-w

 received in 2023-01-27, accepted in 2023-10-05,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundPrimary intracerebral hemorrhage (ICH) accounts for 85% of ICH cases and is associated with high morbidity and mortality rates. Fever can cause secondary injury after ICH; however, relevant studies have reported inconsistent results regarding the effects of fever on functional outcomes after ICH. This study examined the effects of early fever on the prognosis of ICH, particularly on long-term functional outcomes.MethodsThis prospective study recruited patients with primary ICH at a tertiary medical center between 2019 and 2021. Early fever was defined as a tympanic body temperature of ≥ 38 °C upon admission. Barthel Index (BI) and modified Rankin scale (mRS) were examined at 1 year after ICH. A BI of ≤ 60 or mRS of ≥ 4 was considered as indicating severe disability.ResultsWe included 100 patients, and early fever was significantly associated with less functional independence at 1 year post-ICH, as determined using the mRS (p = 0.048; odds ratio [OR] = 0.23), and with severe functional dependency at 1 year post-ICH, as determined using the BI (p = 0.043; OR = 3) and mRS (p = 0.045; OR = 3). In addition, patients with early fever had a longer length of hospital stay (p = 0.002; 95% confidence interval = 21.80–95.91).ConclusionsFever is common among patients with primary ICH. Our data indicate a significant association between early fever and worse functional outcomes in ICH survivors at 1 year after ICH. Additionally, patients with early fever had a significantly longer length of hospital stay after ICH.

【 授权许可】

CC BY   
© BioMed Central Ltd., part of Springer Nature 2023

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