Antihypertensive and antioxidant effects of dietary black sesame meal in pre-hypertensive humans

Nutrition Journal

Research

Patcharee Boonsiri¹  Yaovalak Teerajetgul²  Nongnuch Settasatian²  Suchart Sirijaichingkul³  Nantarat Komanasin⁴  Chatri Settasatian⁵  Naruemon Leelayuwat⁶  Natthida Weerapreeyakul⁷  Jatuporn Wichitsranoi⁸  Nuchanart Rangkadilok⁹ 

[1] Department of Biochemistry, Faculty of Medicine, Khon Kaen University, 40002, Khon Kaen, Thailand;Department of Clinical Chemistry,Faculty of Associated Medical Sciences, Khon Kaen University, 40002, Khon Kaen, Thailand;Department of Clinical Immunology, Faculty of Associated Medical Sciences, Khon Kaen University, 40002, Khon Kaen, Thailand;Department of Clinical Microscopy,Faculty of Associated Medical Sciences, Khon Kaen University, 40002, Khon Kaen, Thailand;Department of Pathology, Faculty of Medicine, Khon Kaen University, 40002, Khon Kaen, Thailand;Department of Physiology, Faculty of Medicine, Khon Kaen University, 40002, Khon Kaen, Thailand;Faculty of Pharmaceutical Sciences, Khon Kaen University, 40002, Khon Kaen, Thailand;Faculty of Physical Therapy, Mahidol University, 73170, Nakhon Pathom, Thailand;Laboratory of Pharmacology, Chulabhorn Research Institute (CRI), Vibhavadee-Rangsit Highway, Laksi, 10210, Bangkok, Thailand;

关键词: blood pressure;    oxidative stress;    malondialdehyde;    sesamin;    sesamolin;    tocopherol;   

DOI  :  10.1186/1475-2891-10-82

 received in 2011-03-11, accepted in 2011-08-09,  发布年份 2011

来源: Springer

【 摘 要 】

BackgroundIt has been known that hypertension is an independent risk factor for cardiovascular disease (CVD). CVD is the major cause of morbidity and mortality in developed and developing countries. Elevation of blood pressure (BP) increases the adverse effect for cardiovascular outcomes. Prevention of increased BP plays a crucial role in a reduction of those outcomes, leading to a decrease in mortality. Therefore, the purpose of this study was to investigate the effects of dietary black sesame meal on BP and oxidative stress in individuals with prehypertension.MethodsTwenty-two women and eight men (aged 49.8 ± 6.6 years) with prehypertension were randomly divided into two groups, 15 subjects per group. They ingested 2.52 g black sesame meal capsules or placebo capsules each day for 4 weeks. Blood samples were obtained after overnight fasting for measurement of plasma lipid, malondialdehyde (MDA) and vitamin E levels. Anthropometry, body composition and BP were measured before and after 4-week administration of black sesame meal or a placebo.ResultsThe results showed that 4-week administration of black sesame meal significantly decreased systolic BP (129.3 ± 6.8 vs. 121.0 ± 9.0 mmHg, P < 0.05) and MDA level (1.8 ± 0.6 vs. 1.2 ± 0.6 μmol/L, P < 0.05), and increased vitamin E level (29.4 ± 6.0 vs. 38.2 ± 7.8 μmol/L, P < 0.01). In the black sesame meal group, the change in SBP tended to be positively related to the change in MDA (R = 0.50, P = 0.05), while the change in DBP was negatively related to the change in vitamin E (R = -0.55, P < 0.05). There were no correlations between changes in BP and oxidative stress in the control group.ConclusionsThese results suggest the possible antihypertensive effects of black sesame meal on improving antioxidant status and decreasing oxidant stress. These data may imply a beneficial effect of black sesame meal on prevention of CVD.

【 授权许可】

Unknown   
© Wichitsranoi et al; licensee BioMed Central Ltd. 2011. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.