Cardiovascular Ultrasound | |
Gene therapy for cardiovascular disease mediated by ultrasound and microbubbles | |
Review | |
Lan Jiang1  Yan Lin1  Zhi-Yi Chen1  Feng Yang1  Shu ping Ge2  | |
[1] Department of Ultrasound Medicine, Key Laboratory for Major Obstetric Diseases of Guangdong Province, The Third Affiliated Hospital of Guangzhou Medical University, 510150, Guangzhou, China;Section of Cardiology, St. Christopher’s Hospital for Children, Drexel University College of Medicine, 3601 A Street, Philadelphia, PA, USA; | |
关键词: Ultrasound; Microbubble; Gene therapy; Cardiovascular; | |
DOI : 10.1186/1476-7120-11-11 | |
received in 2013-03-23, accepted in 2013-04-09, 发布年份 2013 | |
来源: Springer | |
【 摘 要 】
Gene therapy provides an efficient approach for treatment of cardiovascular disease. To realize the therapeutic effect, both efficient delivery to the target cells and sustained expression of transgenes are required. Ultrasound targeted microbubble destruction (UTMD) technique has become a potential strategy for target-specific gene and drug delivery. When gene-loaded microbubble is injected, the ultrasound-mediated microbubble destruction may spew the transported gene to the targeted cells or organ. Meanwhile, high amplitude oscillations of microbubbles increase the permeability of capillary and cell membrane, facilitating uptake of the released gene into tissue and cell. Therefore, efficiency of gene therapy can be significantly improved. To date, UTMD has been successfully investigated in many diseases, and it has achieved outstanding progress in the last two decades. Herein, we discuss the current status of gene therapy of cardiovascular diseases, and reviewed the progress of the delivery of genes to cardiovascular system by UTMD.
【 授权许可】
Unknown
© Chen et al.; licensee BioMed Central Ltd. 2013. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
【 预 览 】
Files | Size | Format | View |
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RO202311104024998ZK.pdf | 4976KB | download |
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