Epitopemap: a web application for integrated whole proteome epitope prediction

BMC Bioinformatics

Software

Damien Farrell¹  Stephen V Gordon¹ 

[1] School of Veterinary Medicine, University College Dublin, Belfield, Dublin, Ireland;

关键词: Epitope;    Web interface;    Antigen;   

DOI  :  10.1186/s12859-015-0659-0

 received in 2015-02-14, accepted in 2015-07-02,  发布年份 2015

来源: Springer

【 摘 要 】

BackgroundPredictions of MHC binding affinity are commonly used in immunoinformatics for T cell epitope prediction. There are multiple available methods, some of which provide web access. However there is currently no convenient way to access the results from multiple methods at the same time or to execute predictions for an entire proteome at once.ResultsWe designed a web application that allows integration of multiple epitope prediction methods for any number of proteins in a genome. The tool is a front-end for various freely available methods. Features include visualisation of results from multiple predictors within proteins in one plot, genome-wide analysis and estimates of epitope conservation.ConclusionsWe present a self contained web application, Epitopemap, for calculating and viewing epitope predictions with multiple methods. The tool is easy to use and will assist in computational screening of viral or bacterial genomes.

【 授权许可】

CC BY   
© Farrell and Gordon. 2015