PIM-1 mRNA expression is a potential prognostic biomarker in acute myeloid leukemia

Journal of Translational Medicine

Research

Xianmin Song¹  Hui Cheng²  Shenglan Gong²  Gusheng Tang²  Chongmei Huang²  Li Chen²  Xiaoqian Xu²  Jianmin Wang²  Jianmin Yang²  Xiaoxia Hu²  Weiping Zhang² 

[1] Department of Hematology, Shanghai First People’s Hospital, Shanghai Jiaotong University, 200433, Shanghai, China;Institute of Hematology, Changhai Hospital, Second Military Medical University, 200433, Shanghai, China;

关键词: PIM-1;    mRNA;    Expression;    Prognosis;    Acute myeloid leukemia;   

DOI  :  10.1186/s12967-017-1287-4

 received in 2017-07-21, accepted in 2017-08-22,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundHigh expression of proviral integration site for Moloney murine leukemia virus-1 (PIM-1), a serine/threonine kinase, is associated with many cancers. The main purpose of this study were to investigate that the correlation between PIM-1 mRNA levels and clinicopathologic features and its clinical significance in acute myeloid leukemia (AML).MethodsqRT-PCR was performed for 118 de novo AML and 20 AML complete remission patients and 15 normal individuals. All statistical analysis were performed using Graphpad Prism5 software.ResultsWe observed that expression of PIM-1 mRNA was higher in AML patients than in healthy individuals and in complete remission AML patients (P = 0.0177). Further, high PIM-1 mRNA levels were more associated with high-risk FLT3+ AML patients than the FLT3− group (P = 0.0001) and were also associated with clinical factors such as risk stratification (P = 0.0029) and vital status (P = 0.0322). Kaplan–Meier survival analysis indicated that PIM-1 mRNA expression correlated with overall survival (OS), disease free survival (DFS), and relapse rate (RR) in AML patients. Most importantly, the high PIM-1-expressing patients took longer to achieve complete remission than the low expression group (P = 0.001). In addition, the complete remission rate was significantly lower in the high PIM-1 group (P = 0.0277) after induction therapy.ConclusionsAbove results suggest that PIM-1 mRNA levels may be an independent prognostic factor in AML.

【 授权许可】

CC BY   
© The Author(s) 2017