Oncolytic virotherapy in veterinary medicine: current status and future prospects for canine patients

Journal of Translational Medicine

Review

Gregory Ogilvie¹  Sandeep S Patil²  Ivaylo Gentschev³  Aladar A Szalay⁴  Ingo Nolte⁵ 

[1] Angel Care Cancer Center, California Veterinary Specialists, 92008, Carlsbad, CA, USA;Department of Radiation Oncology, Moores Cancer Center, University of California, San Diego, 3855 Health Sciences Drive # 0843, 92093, La Jolla, CA, USA;Department of Biochemistry, University of Wuerzburg, D-97074, Wuerzburg, Germany;Department of Biochemistry, University of Wuerzburg, D-97074, Wuerzburg, Germany;Genelux Corporation, San Diego Science Center, San Diego, California, USA;Department of Biochemistry, University of Wuerzburg, D-97074, Wuerzburg, Germany;Genelux Corporation, San Diego Science Center, San Diego, California, USA;Department of Radiation Oncology, Moores Cancer Center, University of California, San Diego, 3855 Health Sciences Drive # 0843, 92093, La Jolla, CA, USA;Rudolf Virchow Center for Experimental Biomedicine, University of Wuerzburg, D-97078, Wuerzburg, Germany;Institute for Molecular Infection Biology, University of Wuerzburg, D-97078, Wuerzburg, Germany;Small Animal Clinic, University of Veterinary Medicine, D-30173, Hannover, Germany;

关键词: cancer;    canine cancer therapy;    oncolytic virus;    oncolysis;    target molecule, combination therapy;   

DOI  :  10.1186/1479-5876-10-3

 received in 2011-10-13, accepted in 2012-01-04,  发布年份 2012

来源: Springer

【 摘 要 】

Oncolytic viruses refer to those that are able to eliminate malignancies by direct targeting and lysis of cancer cells, leaving non-cancerous tissues unharmed. Several oncolytic viruses including adenovirus strains, canine distemper virus and vaccinia virus strains have been used for canine cancer therapy in preclinical studies. However, in contrast to human studies, clinical trials with oncolytic viruses for canine cancer patients have not been reported. An 'ideal' virus has yet to be identified. This review is focused on the prospective use of oncolytic viruses in the treatment of canine tumors - a knowledge that will undoubtedly contribute to the development of oncolytic viral agents for canine cancer therapy in the future.

【 授权许可】

Unknown   
© Patil et al; licensee BioMed Central Ltd. 2012. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.