Impaired lipid metabolism in idiopathic pulmonary alveolar proteinosis

Lipids in Health and Disease

Research

Ruie Feng¹  Yi Xiao²  Yuanjue Zhu²  Lan Wang²  Yaosong Gui²  Juan Wang²  Jinmei Luo²  Kai-Feng Xu²  Xinlun Tian²  Wenbing Xu²  Jiong Zhou³ 

[1] Department of Pathology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, 100730, Beijing, China;Department of Respiratory Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, 100730, Beijing, China;Office for Infection Control, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, 100730, Beijing, China;

关键词: high-density lipoprotein cholesterol;    lipid;    pulmonary alveolar proteinosis;    triglyceride;   

DOI  :  10.1186/1476-511X-10-54

 received in 2011-03-08, accepted in 2011-04-12,  发布年份 2011

来源: Springer

【 摘 要 】

BackgroundIt is well known that lipids abnormally accumulate in the alveoli during idiopathic pulmonary alveolar proteinosis (PAP). It is unclear, however, whether lipids also abnormally accumulate in serum. This study investigated the serum lipid panels in idiopathic PAP patients and explored the relationships between serum levels and the severity of idiopathic PAP.Methods and ResultsClinical data including the level of serum lipids were evaluated in 33 non-diabetic idiopathic PAP patients and 157 healthy volunteers. Serum levels of triglyceride were higher in PAP patients than in healthy subjects (median: 192.00 mg/dl (P25: 104.36, P75: 219.00) vs 119.56 mg/dl (P25: 78.81, P75: 193.03), P < 0.05), while high-density lipoprotein cholesterol (HDL-C) levels were lower in patients than in the control group (42.50 ± 10.30 vs 51.34 ± 12.06 mg/dl, P < 0.01). Forced expiratory volume in one second and forced vital capacity in hypertriglyceridemia patients were lower than those in patients with normal triglyceride. Serum LDL-C and HDL-C ratio correlated negatively with PaO2 (r = -0.403, P < 0.05) and positively with lactate dehydrogenase (r = 0.381, P < 0.05).ConclusionsPAP associates with high triglyceride and low HDL levels in the serum, and these lipids provide potential intervention strategy for treatment.

【 授权许可】

Unknown   
© Tian et al; licensee BioMed Central Ltd. 2011. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.