Inappropriate statistical method in a parallel-group randomized controlled trial results in unsubstantiated conclusions

Nutrition Journal

Letter to the Editor

David B. Allison¹  Rositsa B. Dimova² 

[1] Department of Medicine, Division of Medical Nutrition, Ribeirão Preto Medical School, University of São Paulo, Avenida Bandeirantes, 3900 Bairro Monte Alegre, CEP: 14049-900, Ribeirão Preto, São Paulo, Brazil;Institute of Nutrition, ltu, São Paulo, Brazil;

关键词: Statistical analyses;    Flaxseed;    Research integrity;    Research reporting;    Nutrition;    Obesity;   

DOI  :  10.1186/s12937-016-0163-z

 received in 2015-02-27, accepted in 2016-04-18,  发布年份 2016

来源: Springer

【 摘 要 】

The conclusions of Cassani et al. in the January 2015 issue of Nutrition Journal (doi:10.1186/1475-2891-14-5) cannot be substantiated by the analysis reported nor by the data themselves. The authors ascribed the observed decrease in inflammatory markers to the components of flaxseed and based their conclusions on within-group comparisons made between the final and the baseline measurements separately in each arm of the randomized controlled trial. However, this is an improper approach and the conclusions of the paper are invalid. A correct analysis of the data shows no such effects.

【 授权许可】

CC BY   
© Dimova and Allison. 2016