Acute monoarthritis in a delayed diagnosis of syphilis patient with persistent rupioid psoriasis-like lesions

BMC Infectious Diseases

Case Report

Qiang Zhou¹  Rui Han¹  Kejian Zhu¹  Hao Cheng¹ 

[1] Department of Dermatology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, No. 3 Qingchun Road East, Hangzhou, Zhejiang, China;

关键词: Syphilis;    Monoarthritis;    Rupioid psoriasis-like plaque;   

DOI  :  10.1186/1471-2334-12-338

 received in 2012-07-17, accepted in 2012-11-29,  发布年份 2012

来源: Springer

【 摘 要 】

BackgroundThe incidence of syphilis is increasing in many parts of the world. Clinicians may have limited experience in the diagnosis when the clinical appearance is unusual. If early diagnosis is not made and prompt treatment not given, then the disease may remain quiescent until more serious symptoms or systemic involvement develops.Case presentationWe report the first case of a delayed diagnosis of syphilis with a ten-year history of persistent rupioid psoriasis-like lesions. Acute monoarthritis and high fever together with aggravation of skin lesions led to a careful clinical examination. Skin biopsies demonstrated syphilis spirochetes on immunohistochemical stain, and syphilis serological titers were positive. Standard treatment with benzathine penicillin brought a partial and transient improvement. A complete clinical and serological resolution of the disease was achieved by a prolonged and repeated penicillin treatment combined with methylprednisolone. A 7-year follow-up of the patient proved a full recovery.ConclusionOur case highlights the fact that clinical signs of syphilis can be diverse and complicated. Unusual clinical manifestations can happen in an immunocompetent individual. Treatment strategy may need to be adjusted in a difficult case.

【 授权许可】

Unknown   
© Zhu et al.; licensee BioMed Central Ltd. 2012. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.