The role of lifestyle changes in the management of chronic liver disease

BMC Medicine

Review

Christine Carter-Kent¹  Ariel E Feldstein²  Valerio Nobili³ 

[1] Department of Pediatric Gastroenterology, Cleveland Clinic, 9500 Euclid Avenue, 44195, Cleveland, OH, USA;Department of Pediatric Gastroenterology, Cleveland Clinic, 9500 Euclid Avenue, 44195, Cleveland, OH, USA;Department of Cell Biology, Cleveland Clinic, 9500 Euclid Avenue44195, Cleveland, OH, USA;Metabolic and Autoimmunity Liver Unit, "Bambino Gesù" Children's Hospital and Research Institute, S. Onofrio Square, 4, 00165, Rome, Italy;

关键词: Metabolic Syndrome;    Chronic Hepatitis;    Chronic Liver Disease;    Lifestyle Intervention;    Hepatic Steatosis;   

DOI  :  10.1186/1741-7015-9-70

 received in 2010-12-13, accepted in 2011-06-06,  发布年份 2011

来源: Springer

【 摘 要 】

The prevalence of obesity worldwide has dramatically increased during the last three decades. With obesity comes a variety of adverse health outcomes which are grouped under the umbrella of metabolic syndrome. The liver in particular seems to be significantly impacted by fat deposition in the presence of obesity. In this article we discuss several liver conditions which are directly affected by overweight and obese status, including non-alcoholic fatty liver disease, chronic infection with hepatitis C virus and post-liver transplant status. The deleterious effects of obesity on liver disease and overall health can be significantly impacted by a culture that fosters sustained nutritional improvement and regular physical activity. Here we summarize the current evidence supporting non-pharmacological, lifestyle interventions that lead to weight reduction, improved physical activity and better nutrition as part of the management and treatment of these liver conditions.

【 授权许可】

CC BY   
© Nobili et al; licensee BioMed Central Ltd. 2011