Skin autofluorescence is associated with inappropriate left ventricular mass and diastolic dysfunction in subjects at risk for cardiovascular disease

Cardiovascular Diabetology

Original Investigation

Yen-Lin Chang¹  An-Sheng Lee²  Yao-Chang Wang³  Hung-Chih Chen⁴  Chiz-Tzung Chang⁵  Show-Yih Liou⁶  Wei-Yu Chen⁷  Ming-Yi Shen⁸  Guei-Jane Wang⁹  Chun-Cheng Wang^1,10  Kuan-Cheng Chang^1,11 

[1] Department of Biomedical Engineering, Chun Yuan Christian University, Taoyuan, Taiwan;Department of Medicine, Mackay Medical College, New Taipei, Taiwan;Division of Cardiothoracic Surgery, Chang Gung Memorial Hospital Keelung Branch, Keelung, Taiwan;Division of Nephrology, Department of Internal Medicine, China Medical University Hospital, Taichung, Taiwan;Division of Nephrology, Department of Internal Medicine, China Medical University Hospital, Taichung, Taiwan;College of Medicine, China Medical University, No. 91, Hsueh-Shih Road, 40402, Taichung, Taiwan;Cardiovascular Research Laboratory, China Medical University Hospital, Taichung, Taiwan;Formosan Blood Purification Foundation, Taipei, Taiwan;Graduate Institute of Basic Medical Science, China Medical University, No. 91, Hsueh-Shih Road, 40402, Taichung, Taiwan;Graduate Institute of Clinical Medical Science, China Medical University, No. 91, Hsueh-Shih Road, 40402, Taichung, Taiwan;Graduate Institute of Clinical Medical Science, China Medical University, No. 91, Hsueh-Shih Road, 40402, Taichung, Taiwan;Department of Medical Research, China Medical University Hospital, Taichung, Taiwan;Department of Health and Nutrition Biotechnology, Asia University, Taichung, Taiwan;Graduate Institute of Clinical Medical Science, China Medical University, No. 91, Hsueh-Shih Road, 40402, Taichung, Taiwan;Division of Cardiology, Department of Internal Medicine, Taichung Tzuchi Hospital, The Buddhist Tzuchi Medical Foundation, Taichung, Taiwan;Division of Cardiovascular Medicine, Department of Internal Medicine, China Medical University Hospital, Taichung, Taiwan;Graduate Institute of Clinical Medical Science, China Medical University, No. 91, Hsueh-Shih Road, 40402, Taichung, Taiwan;Division of Cardiovascular Medicine, Department of Internal Medicine, China Medical University Hospital, Taichung, Taiwan;College of Medicine, China Medical University, No. 91, Hsueh-Shih Road, 40402, Taichung, Taiwan;Cardiovascular Research Laboratory, China Medical University Hospital, Taichung, Taiwan;

关键词: Advanced glycation end product;    Skin autofluorescence;    Inappropriate left ventricular mass;    Diastolic dysfunction;   

DOI  :  10.1186/s12933-017-0495-9

 received in 2016-09-28, accepted in 2017-01-11,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundEnhanced advanced glycation end products deposition within myocardial tissue may cause diastolic dysfunction. However, whether this is related to left ventricular hypertrophy or inappropriate left ventricular mass remains unclear.MethodsWe prospectively enrolled 139 subjects at risk for cardiovascular diseases. We used echocardiography for measurements of left ventricular mass and cardiac systolic and diastolic functional parameters. An advanced glycation end product reader was applied for measurements of skin autofluorescence values. Comparisons of left ventricular mass and echocardiographic parameters between the higher and lower skin autofluorescence groups were analyzed.ResultsCompared with the lower skin autofluorescence group, left ventricular mass index and the ratio of observed left ventricular mass/predicted left ventricular mass (oLVM/pLVM) was significantly higher in the higher skin autofluorescence group (61.22 ± 17.76 vs. 47.72 ± 11.62, P < 0.01, 1.62 ± 0.38 vs. 1.21 ± 0.21, P < 0.01). After adjustment for potential confounding factors, skin autofluorescence was an independent factor for left ventricular mass index (β = 0.32, P < 0.01) and the ratio of oLVM/pLVM (β = 0.41, P < 0.01). Skin autofluorescence ≥2.35 arbitrary unit predicted left ventricular hypertrophy at a sensitivity of 58.8%, and a specificity of 73.0% (P < 0.01). Skin autofluorescence ≥2.25 arbitrary unit predicted inappropriate left ventricular mass at a sensitivity of 71.1%, and a specificity of 83.9% (P < 0.01). Skin autofluorescence was positively correlated with E/E′, an indicator for diastolic dysfunction (r = 0.21, P = 0.01).ConclusionsSkin autofluorescence is a useful tool for detecting left ventricular hypertrophy, inappropriate left ventricular mass and diastolic dysfunction.

【 授权许可】

CC BY   
© The Author(s) 2017