Trends in clinical features, postoperative outcomes, and long-term survival for gastric cancer: a Western experience with 1,278 patients over 30 years

World Journal of Surgical Oncology

Research

Guido Costamagna¹  Giovanni Battista Doglietto²  Claudio Fiorillo²  Sergio Alfieri²  Fausto Rosa²  Antonio Pio Tortorelli² 

[1] Department of Digestive Endoscopy, Catholic University, “A. Gemelli” Hospital, Rome, Italy;Department of Digestive Surgery, Catholic University, “A. Gemelli” Hospital, Largo A. Gemelli, 8, 00168, Rome, Italy;

关键词: Gastric cancer;    Surgery;    Long-term survival;   

DOI  :  10.1186/1477-7819-12-217

 received in 2014-03-21, accepted in 2014-07-04,  发布年份 2014

来源: Springer

【 摘 要 】

BackgroundThe aim of the present study was to identify temporal trends in long-term survival and postoperative outcomes and to analyze prognostic factors influencing the prognosis of patients with gastric cancer (GC) treated in a 30-year interval in a tertiary referral Western institution.MethodsBetween January 1980 and December 2010, 1,278 patients who were diagnosed with GC at the Digestive Surgery Department, Catholic University of Rome, Italy, were identified. Among them, 936 patients underwent surgical resection and were included in the analysis.ResultsOver time there was a significant improvement in postoperative outcomes. Morbidity and mortality rates decreased to 19.4% and 1.6%, respectively, in the last decade. By contrast, the multivisceral resection rate steadily increased from 12.7% to 29.6%. The overall five-year survival rate steadily increased over time, reaching 51% in the last decade, and 64.5% for R0 resections. Multivariate analysis showed a higher probability of overall survival for early stages (I and II), extended lymphadenectomy, and R0 resections.ConclusionsOver three decades there was a significant improvement in perioperative and postoperative care and a steady increase in overall survival.

【 授权许可】

CC BY   
© Rosa et al.; licensee BioMed Central Ltd. 2014