Novel association patterns of cardiac remodeling markers in patients with essential hypertension and atrial fibrillation

BMC Cardiovascular Disorders

Research Article

Angelos G Rigopoulos¹  Dimitrios TH Kremastinos¹  Ioannis Rizos¹  Eleftherios A Sakadakis¹  Andreas Triantafyllis¹  Sotirios Tsiodras²  Andreas S Kalogeropoulos³ 

[1] 2nd Department of Cardiology, University of Athens Medical School, Attikon University Hospital, Athens, Greece;4th Academic Department of Internal Medicine and Infectious Diseases, University of Athens Medical School, Attikon University Hospital, Athens, Greece;Department of Cardiology, Hammersmith Hospital, Imperial College Healthcare NHS Trust, London, UK;

关键词: Atrial Fibrillation;    Sinus Rhythm;    Paroxysmal Atrial Fibrillation;    Atrial Fibrillation Patient;    Left Atrial Volume;   

DOI  :  10.1186/1471-2261-11-77

 received in 2011-08-01, accepted in 2011-12-28,  发布年份 2011

来源: Springer

【 摘 要 】

BackgroundMatrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) are essential for the cardiac extracellular matrix (ECM) remodeling. We investigated differences in serum levels of these markers between patients with atrial fibrillation (AF) and sinus rhythm (SR).MethodsSerum levels of MMP-2, MMP-3, MMP-9 and TIMP-1 were measured in 86 patients: 27 on SR without any AF history, 33 with paroxysmal and 26 with permanent AF. All subjects had essential hypertension, normal systolic function and no coronary artery disease.ResultsPatients with AF had higher MMP-2, MMP-3 and MMP-9 and lower TIMP-1 compared to SR subjects (all p < 0.001). Paroxysmal AF was associated with higher MMP-2 levels compared to permanent AF (p < 0.001). Matrix metalloproteinase-9 but not MMP-3 was higher in permanent compared to paroxysmal AF group (p < 0.001). Patients with AF had lower levels of TIMP-1 compared to those with SR while permanent AF subjects had lower TIMP-1 levels than those with paroxysmal AF (p < 0.001 for both comparisons). Lower TIMP-1 was the only independent factor associated with AF (OR: 0.259, 95%CI: 0.104-0.645, p = 0.004).ConclusionsIn hypertensives, paroxysmal AF and permanent AF differ with respect to serum MMPs. Increased MMP-2 is associated with paroxysmal, whereas increased MMP-9 with permanent AF. Additionally, lower levels of TIMP-1 had a strong association with AF incidence.

【 授权许可】

CC BY   
© Kalogeropoulos et al; licensee BioMed Central Ltd. 2011