Association of breastfeeding with mental disorders in mother and child: a systematic review and meta-analysis

BMC Medicine

Research Article

Polina Bugaeva¹  Aleksandra Pokrovskaya²  Svetlana Gadetskaya³  Anastasia Kolotilina³  Aigun Mursalova³  Elena Kondrikova³  Dina Baimukhambetova³  Gabriel Torbahn⁴  Jon Genuneit⁵  Derek K. Chu⁶  Yasmin El-Taravi⁷  Timothy R. Nicholson⁸  Igor Kamenskiy⁹  Mikhail Zinchuk^1,10  Renat Akzhigitov^1,10  Alla Guekht^1,10  Rinat Bikaev^1,10  Robert J. Boyle^1,11  Daniel Munblit^1,12  Valeria Caso^1,13  Alla Avedisova^1,14  Inna Arkusha^1,15 

[1] Charité – Universitätsmedizin Berlin, Einstein Center for Neurosciences, Berlin, Germany;Department of Brain Sciences, Faculty of Medicine, Dementia Research Institute UK, Imperial College London, London, UK;Department of Paediatrics and Paediatric Infectious Diseases, Institute of Child’s Health, I.M. Sechenov First Moscow State Medical University, Sechenov University, Moscow, Russia;Department of Pediatrics, Paracelsus Medical University, Klinikum Nürnberg, Universitätsklinik Der Paracelsus Medizinischen Privatuniversität Nürnberg, Nuremberg, Germany;Department of Pediatrics, Paracelsus Medical University, Salzburg, Austria;Department of Pediatrics, Pediatric Epidemiology, Medical Faculty, Leipzig University, Leipzig, Germany;German Center for Child and Youth Health, Leipzig, Germany;Division of Clinical Immunology & Allergy, Department of Medicine, and Department of Health Research Methods, Evidence & Impact, McMaster University, Hamilton, Canada;Endocrinology Research Centre, Moscow, Russia;Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London, UK;Moscow City Clinical Hospital After V.M. Buyanov, Moscow, Russia;Moscow Research and Clinical Centre for Neuropsychiatry, Moscow, Russia;National Heart and Lung Institute, Imperial College London, London, UK;National Heart and Lung Institute, Imperial College London, London, UK;Care for Long Term Conditions Division, Florence Nightingale Faculty of Nursing, Midwifery and Palliative Care, King’s College London, London, UK;I.M. Sechenov First Moscow State Medical University, Sechenov University, Moscow, Russia;Department of Infectious Disease, Faculty of Medicine, Imperial College London, London, United Kingdom;Stroke Unit, Santa Maria Della Misericordia Hospital, University of Perugia, Perugia, Italy;V. Serbsky Federal Medical Research Center for Psychiatry and Narcology of the Ministry of Health of the Russian Federation, Moscow, Russia;V. Serbsky Federal Medical Research Center for Psychiatry and Narcology of the Ministry of Health of the Russian Federation, Moscow, Russia;Moscow Research and Clinical Centre for Neuropsychiatry, Moscow, Russia;

关键词: Anxiety disorders;    Breastfeeding;    Child health;    Depressive disorders;    Maternal health;    Mental health;    Schizophrenia;    Systematic review;   

DOI  :  10.1186/s12916-023-03071-7

 received in 2023-03-07, accepted in 2023-09-06,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundBreastfeeding has long been associated with numerous benefits for both mothers and infants. While some observational studies have explored the relationship between breastfeeding and mental health outcomes in mothers and children, a systematic review of the available evidence is lacking. The purpose of this study is to systematically evaluate the association between breastfeeding and mental health disorders in mothers and children.MethodsWe systematically searched MEDLINE and EMBASE from inception to June 2, 2023. The inclusion criteria consisted of all studies evaluating links between breastfeeding and development of mental health disorders in children and mothers. Risk of bias was assessed using the Newcastle–Ottawa Scale (NOS) while grading of Recommendations Assessment, Development and Evaluation (GRADE) was used to assess the certainty of evidence. A random-effects meta-analysis was used if possible, to estimate the odds ratio for the association between breastfeeding and mental health outcomes. The Mantel–Haenszel method was utilised for pooling ORs across studies. Study heterogeneity was assessed using the I2 statistic.ResultsOur review identified twenty-one original study. Of these, 18 focused on the association between breastfeeding and child health, assessing depressive disorders, schizophrenia, anxiety disorders, eating disorders and borderline personality disorder. Three studies evaluated the associations between breastfeeding and maternal mental health disorders. Three studies looking at outcomes in children showed no significant association between breastfeeding and occurrence of schizophrenia later in life (OR 0.98; 95% CI 0.57–1.71; I2 = 29%). For depressive disorders (5 studies) and anxiety disorders (3 studies), we found conflicting evidence with some studies showing a small protective effect while others found no effect. The GRADE certainty for all these findings was very low due to multiple limitations. Three studies looking at association between breastfeeding and maternal mental health, were too heterogeneous to draw any firm conclusions.ConclusionsWe found limited evidence to support a protective association between breastfeeding and the development of mental health disorders in children later in life. The data regarding the association between breastfeeding and maternal mental health beyond the postnatal period is also limited. The methodological limitations of the published literature prevent definitive conclusions, and further research is needed to better understand the relationship between breastfeeding and mental health in mothers and children.

【 授权许可】

CC BY   
© BioMed Central Ltd., part of Springer Nature 2023

【 图 表 】

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