Downregulation of metastasis suppressor 1(MTSS1) is associated with nodal metastasis and poor outcome in Chinese patients with gastric cancer

BMC Cancer

Research Article

Guanzhen Yu¹  Jiejun Wang¹  Ke Liu¹  Gefang Wang²  Ying Chen³  Houzhong Ding⁴ 

[1] Department of Medical Oncology, Changzheng Hospital, Shanghai, China;Department of Oncology, the Eighty-fifth Hospital, Shanghai, China;Department of Pathology, Changhai Hospital, Shanghai, China;Department of Surgery, the first People's Hospital, Kunshan, Jiangsu, China;

关键词: Gastric Cancer;    Gastric Carcinoma;    Metastasis Suppressor;    Bladder Cancer Cell Line;    Normal Adjacent Mucosa;   

DOI  :  10.1186/1471-2407-10-428

 received in 2010-01-04, accepted in 2010-08-15,  发布年份 2010

来源: Springer

【 摘 要 】

BackgroundThe putative tumor metastasis suppressor 1(MTSS1) is an actin-binding scaffold protein that has been implicated to play an important role in carcinogenesis and cancer metastasis, yet its role in the development of gastric cancer has not been well illustrated. In this study, we detected MTSS1 expression and explored its clinical significance in gastric cancer.MethodsImmunohistochemistry was performed using tissue microarrays containing gastric adenocarcinoma specimens from 1,072 Chinese patients with normal adjacent mucosa, primary gastric cancer and lymph node (LN) metastasis and specific antibody against MTSS1. MTSS1 mRNA and protein expression were detected by reverse transcription-polymerase chain reaction and Western blotting. The clinical follow-up was done in the 669 patients living in Shanghai that was chose from the 1072 cases.ResultsComplete loss of MTSS1 expression was observed in 751 cases (70.1%) of the 1,072 primary tumors and 103 (88%) of 117 nodal metastases; and loss of MTSS1 expression was significantly associated with poorly differentiated tumors, large tumor size, deep invasion level, the presence of nodal metastases and advanced disease stage. Moreover, multivariate analysis demonstrated that loss of MTSS1 expression correlated significantly with poor survival rates (RR = 0.194, 95% CI = 0.144-0.261, P < 0.001).ConclusionsMTSS1 expression decreased significantly as gastric cancer progressed and metastasized, suggesting MTSS1 may serve as a useful biomarker for the prediction of outcome of gastric cancer.

【 授权许可】

Unknown   
© Liu et al; licensee BioMed Central Ltd. 2010. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.