Comprehensive left ventricular mechanics analysis by speckle tracking echocardiography in Chagas disease

Cardiovascular Ultrasound

Research

Hector R. Villarraga¹  Marta Fernandes Lima²  Marcio Sommer Bittencourt²  Marcio Silva Miguel Lima²  Maria Cristina Donadio Abduch²  Wilson Mathias²  Cecilia Beatriz Bittencourt Viana Cruz²  Joao Cesar Nunes Sbano²  Jeane Mike Tsutsui²  Mariana Callil Voos² 

[1] Mayo Clinic and Mayo Foundation, Rochester, MN, USA;Serviço de Ecocardiografia, Instituto do Coração (InCor), University of Sao Paulo Medical School, Av Dr Eneas de Carvalho Aguiar, 44, Cerqueira Cesar, 05.403-000, Sao Paulo, SP, Brazil;

关键词: Speckle tracking echocardiography;    Cardiomyopathies;    Cardiac mechanics;    Strain;   

DOI  :  10.1186/s12947-016-0062-7

 received in 2016-03-24, accepted in 2016-05-14,  发布年份 2016

来源: Springer

【 摘 要 】

BackgroundChagas disease (CD) is a frequent cause of dilated cardiomyopathy (CMP) in developing countries, leading to clinical heart failure and worse prognosis. Therefore, the development and evolution of this CMP has always been a major topic in numbers of previous studies. A comprehensive echocardiographic study of left ventricular (LV) mechanics, fully assessing myocardial contraction, has never been done before. This could help characterize and improve the understanding of the evolution of this prevalent CMP.MethodsA total of 47 chagasic and 84 control patients were included in this study and allocated in groups according to LV ejection fraction. 2D-Echocardiogram was acquired for LV mechanics analysis by speckle tracking echocardiography.ResultsMean age of chagasic individuals was 55y and 16 (34 %) were men. Significant difference was found in global longitudinal velocity analysis, with lower values in indeterminate form. In the group with severe systolic dysfunction, a paradoxical increase in longitudinal and apical radial displacements were demonstrated. In parallel, segmental analyzes highlighted lower values of radial displacement, strain and strain rate into inferior and inferolateral walls, with increase of these values in septal and anterior walls.ConclusionChagasic CMP has a vicarious pattern of contraction in the course of its evolution, defined by reduced displacement and strain into inferior and posterior walls with paradoxical increase in septal and anterior segments. Also, lower longitudinal velocities were demonstrated in CD indeterminate form, which may indicate an incipient myocardial injury.

【 授权许可】

CC BY   
© Lima et al. 2016