Growth differentiation factor–15 predicts the prognoses of patients with acute coronary syndrome: a meta-analysis

BMC Cardiovascular Disorders

Research Article

Qi Lu¹  Fengying Yi¹  Ruochi Zhao¹  Hanbin Cui¹  Xiangxiang Wan¹  Shangshi Zhang²  Hongyan Zhu³  Liting Jiang⁴  Dongjun Dai⁴  Xian Wang⁴  Hongchuan Jin⁴ 

[1] Department of Cardiovascular, Ningbo First Hospital, 315010, Ningbo, China;Department of Cardiovascular, Ningbo First Hospital, 315010, Ningbo, China;Department of Cardiovascular, Shangrao People ’s Hospital, 334000, Shangrao, China;Department of Cardiovascular, Shangrao People ’s Hospital, 334000, Shangrao, China;Department of Medical Oncology, Institute of Clinical Science, Sir Run Run Shaw Hospital, Medical School of Zhejiang University, 310029, Hangzhou, China;

关键词: Acute Coronary Syndrome;    Acute Coronary Syndrome Patient;    Takotsubo Cardiomyopathy;    Recurrent Myocardial Infarction;    High Hazard Ratio;   

DOI  :  10.1186/s12872-016-0250-2

 received in 2015-08-11, accepted in 2016-04-15,  发布年份 2016

来源: Springer

【 摘 要 】

BackgroundRecent studies have shown Growth differentiation factor–15 (GDF-15) that is a member of the transforming growth factor β (TGF-β) superfamily might be a potential predictive cytokine for the prognosis of Acute coronary syndrome (ACS). However, there are discrepancies in these studies.MethodsPublication searches of the PubMed/Medline and EMBASE databases were performed without any time or ethnicity restrictions. The inclusion and exclusion criteria, when clear, were addressed. Random effects models were used for all analyses. Publication bias was tested using funnel plots and the Egger test.ResultsWe identified eight eligible studies that provided mortality data. Five of these studies provided recurrent myocardial infarction (MI) data. The maximal duration of follow-up ranged from 6 months to 6 years. A significant association was found between the patients with the highest and lowest GDF-15 levels (overall analyses) in terms of mortality (p < 0.00001; RR = 6.08; 95 % CI = 4.79–7.71) and recurrent MI (p < 0.00001; RR = 1.76; 95 % CI = 1.49–2.07). We also found significant associations between the subgroup analyses stratified by ACS types, cutoff points and follow-up durations (p < 0.001). The combined hazard ratio was high for GDF-15 to ACS (HR = 1.656, 95 % CI = 1.467–1.871).ConclusionHigh plasma GDF-15 levels are associated with an increased risk of mortality and recurrent MI in patients with ACS.

【 授权许可】

CC BY   
© Zhang et al. 2016