Evaluation of ivermectin mass drug administration for malaria transmission control across different West African environments

Malaria Journal

Research

Haoues Alout¹  Doug E Brackney¹  Brian D Foy¹  Benjamin J Krajacich¹  Nathan D Grubaugh¹  Jacob I Meyers²  Abdoulaye Diabaté³  Roch K Dabiré³  Lawrence S Fakoli⁴  Fatorma K Bolay⁴  Roland W Bougma⁵  Joseph W Diclaro⁶  Kevin C Kobylinski⁷ 

[1] Arthropod-borne and Infectious Diseases Laboratory, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO, USA;Arthropod-borne and Infectious Diseases Laboratory, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO, USA;Department of Biomedical Sciences, Colorado State University, Fort Collins, CO, USA;Institut de Recherche en Sciences de la Santé (IRSS), Direction Régionale de l’Ouest (DRO), Bobo Dioulasso, Burkina Faso;Liberian Institute for Biomedical Research, Charlesville, Liberia;Ministry of Health, Ouagadougou, Burkina Faso;US Naval Medical Research Unit No 3, Cairo, Egypt;Walter Reed Army Institute of Research, 503 Robert Grant Ave, Silver Spring, MD, USA;Armed Forces Research Institute of Medical Sciences, 315/6 Rajvithi Road, Bangkok, Thailand;

关键词: Mass drug administration;    Ivermectin;    Transmission;    West Africa;    Malaria control;    Plasmodium falciparum;    Anopheles gambiae;    Survival;    Parity;    Environment;   

DOI  :  10.1186/1475-2875-13-417

 received in 2014-08-30, accepted in 2014-10-25,  发布年份 2014

来源: Springer

【 摘 要 】

BackgroundMass drug administration (MDA) of ivermectin to humans for control and elimination of filarial parasites can kill biting malaria vectors and lead to Plasmodium transmission reduction. This study examines the degree and duration of mosquitocidal effects resulting from single MDAs conducted in three different West African countries, and the subsequent reductions in parity and Plasmodium sporozoite rates.MethodsIndoor-resting, blood-fed and outdoor host-seeking Anopheles spp. were captured on days surrounding MDAs from 2008–2013 in Senegalese, Liberian and Burkinabé villages. Mortality was assessed on a portion of the indoor collection, and parity status was determined on host-seeking mosquitoes. The effect of MDA was then analysed against the time relative to the MDA, the distributed drugs and environmental variables.ResultsAnopheles gambiae survivorship was reduced by 33.9% for one week following MDA and parity rates were significantly reduced for more than two weeks after the MDAs. Sporozoite rates were significantly reduced by >77% for two weeks following the MDAs in treatment villages despite occurring in the middle of intense transmission seasons. These observed effects were consistent across three different West African transmission dynamics.ConclusionsThese data provide a comprehensive and crucial evidence base for the significant reduction in malaria transmission following single ivermectin MDAs across diverse field sites. Despite the limited duration of transmission reduction, these results support the hypothesis that repeated MDAs with optimal timing could help sustainably control malaria as well as filarial transmission.

【 授权许可】

CC BY   
© Alout et al.; licensee BioMed Central Ltd. 2014