TAS2R38 taste receptor gene and chronic rhinosinusitis: new data from an Italian population

BMC Medical Genetics

Research Article

Daniel Simmen¹  Giulia Montrasio²  Stefania Gallo³  Paolo Castelnuovo³  Giorgio Binelli⁴  Raffaella Cinquetti⁴  Sarah Grossi⁴  Paola Campomenosi⁵ 

[1]Center for Rhinology, Skull Base Surgery and Facial Plastic Surgery, ORL-Zentrum, Klinik Hirslanden, Zurich, Switzerland

[2]Clinica Otorinolaringoiatrica, Ospedale di Circolo e Fondazione Macchi, Università degli Studi dell’Insubria, Varese, Italy

[3]Clinica Otorinolaringoiatrica, Ospedale di Circolo e Fondazione Macchi, Università degli Studi dell’Insubria, Varese, Italy

[4]Dipartimento di Biotecnologie e Scienze della Vita (DBSV), Università dell’Insubria, Via J.H. Dunant, 3, 21100, Varese, Italy

[5]Dipartimento di Biotecnologie e Scienze della Vita (DBSV), Università dell’Insubria, Via J.H. Dunant, 3, 21100, Varese, Italy

[6]Dipartimento di Biotecnologie e Scienze della Vita (DBSV), Università dell’Insubria, Via J.H. Dunant, 3, 21100, Varese, Italy

[7]The Protein Factory, Centro Interuniversitario di Ricerca in Biotecnologie Proteiche, Politecnico di Milano, ICRM-CNR Milano and Università degli Studi dell’Insubria, Varese, Italy

关键词: Bitter taste receptor T2R38;    Chronic rhinosinusitis;    Pathogenesis;    Genotyping;    TAS2R38;   

DOI  :  10.1186/s12881-016-0321-3

 received in 2015-06-28, accepted in 2016-06-10,  发布年份 2016

来源: Springer

【 摘 要 】

BackgroundChronic rhinosinusitis (CRS) is a frequent disease with high social impact and multifactorial pathogenesis. Recently, single nucleotide polymorphisms within the TAS2R38 gene have been implicated as possible contributors to the complex gene-environment interactions in CRS.The purpose of this study was to confirm the proposed correlation between TAS2R38 genotype, CRS and related comorbidities.MethodsFifty-three CRS patients and 39 healthy individuals were genotyped at the TAS2R38 locus. CRS patients were treated by endoscopic sinus surgery and medical therapies and subdivided in CRS with nasal polyps (CRSwNPs) and CRS without nasal polyps (CRSsNPs). The effect of genotype on CRS and CRS-related comorbidities was assessed.ResultsThe distribution of the different genotypes at the TAS2R38 locus was not significantly different between CRS patients, either with or without nasal polyps, and controls. Besides, no association was found between the different genotypes at the TAS2R38 locus and CRS-related comorbidities.ConclusionsNo association was found between TAS2R38 alleles or genotypes and CRS, thus questioning its role in the pathogenesis of CRS.

【 授权许可】

CC BY   
© The Author(s). 2016