Ten-year radiographic and functional outcomes in rheumatoid arthritis patients in remission compared to patients in low disease activity

Arthritis Research & Therapy

Research

Olivier Vittecoq¹  Gregory Guernec²  Yannick Degboé³  Arnaud Constantin³  Adeline Ruyssen-Witrand⁴  Julia Dupont⁵  Diane Lapuyade⁵  Frédéric Lioté⁶ 

[1] Department of Rheumatology and CIC-CRB1404, Normandie Univ, UNIROUEN, Rouen University Hospital, 76000, Rouen, France;Inserm, Centre d’Epidémiologie Et de Recherche en Santé Des Populations, UMR1295, Inserm, Toulouse, France;Rheumatology Center, Toulouse University Hospital, INFINITY, Toulouse Institute for Infectious and Inflammatory Diseases, INSERM U1291, CNRS U5051, University Toulouse 3, Toulouse, France;Rheumatology Centre, Toulouse University Hospital, Centre d’Investigation Clinique de Toulouse CIC1436, Inserm, Team PEPSS “Pharmacologie En Population cohorteS Et biobanqueS, Purpan Teaching Hospital, University of Toulouse 3, 1 Place du Dr Baylac, 31059, Toulouse, Cedex 9, France;Rheumatology Centre, Toulouse University Hospital, Toulouse, France;Université Paris Cité and Inserm UMR1132 Bioscar Hôpital Lariboisière and Service de Rhumatologie, Hôpital Saint-Joseph, Paris, France;

关键词: Rheumatoid arthritis;    Prognosis;    Long-term outcomes;    Remission;    Disease activity;   

DOI  :  10.1186/s13075-023-03176-7

 received in 2023-06-02, accepted in 2023-09-19,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundTo compare the 10-year structural and functional prognosis between patients in sustained remission versus patients in sustained low disease activity (LDA) in early rheumatoid arthritis (RA).MethodsWe included 256 patients from the ESPOIR cohort who fulfilled the 2010 ACR/EULAR criteria for RA and who were in sustained remission using the Simple Disease Activity Index (SDAI) score (n = 48), in sustained LDA (n = 139) or in sustained moderate to high disease activity (MDA or HDA, n = 69) over 10 years. The mTSSs progression over 10 years and the 10-year HAQ-DI scores were compared between the 3 groups. A longitudinal latent process mixed model was used to assess the independent effect of SDAI status over time on 10-year mTSS progression and HAQ-DI at 10 years.ResultsPatients in sustained remission group were younger, had lower baseline HAQ-DI and mTSS scores and were less exposed to glucocorticoids, methotrexate or biologic disease-modifying anti-rheumatic drugs over 10 years. Patients in sustained remission had lower 10-year structural progression (variation of mTSS in the remission group: 4.06 (± 4.75) versus 14.59 (± 19.76) in the LDA group and 21.04 (± 24.08), p < 0.001 in the MDA or HDA groups) and lower 10-year HAQ-DI scores (10-year HAQ-DI in the remission group: 0.14 (± 0.33) versus 0.53 (± 0.49) in the LDA group and 1.20 (± 0.62) in the MDA or HDA groups, p < 0.001). The incidence of serious adverse events over 10 years was low, about 3.34/100 patient years, without any difference between the three groups.ConclusionRA patients in sustained SDAI remission have better long-term structural and functional outcomes in comparison to patients in sustained LDA.

【 授权许可】

CC BY   
© BioMed Central Ltd., part of Springer Nature 2023

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