Association between remnant cholesterol, metabolic syndrome, and cardiovascular disease: post hoc analysis of a prospective national cohort study

European Journal of Medical Research

Research

Melissa Francois¹  Yingling Zhou²  Ping Zeng²  Junguo Jin²  Xiangming Hu²  Haojian Dong³  Bingyan Yu⁴  Weimian Wang⁵ 

[1] College of Medicine, SUNY Upstate Medical University, 13210, Syracuse, NY, USA;Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, 510080, Guangzhou, Guangdong, China;Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, 510080, Guangzhou, Guangdong, China;Nyingchi People’s Hospital, 860000, Nyingchi, Tibet, China;Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, 510080, Guangzhou, Guangdong, China;School of Medicine, South China University of Technology, 510006, Guangzhou, China;Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, 510080, Guangzhou, Guangdong, China;The Second School of Clinical Medicine, Southern Medical University, 510515, Guangzhou, Guangdong, China;

关键词: Remnant cholesterol;    Metabolic syndrome;    Inflammation;    Insulin resistance;    Cardiovascular disease;   

DOI  :  10.1186/s40001-023-01369-z

 received in 2023-03-07, accepted in 2023-09-13,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundEpidemiologic evidence suggested that remnant cholesterol (RC) is associated with the occurrence of cardiovascular disease (CVD). In recent years, RC has been connected with different types of cardiometabolic disorders. We aim to clarify the relationship among RC, metabolic syndrome (MetS) and subsequent CVD.MethodsWe enrolled 7471 individuals into our study from China Health and Nutrition Survey in 2009 and followed participants till 2015. RC was calculated as total cholesterol minus low-density lipoprotein cholesterol minus high-density lipoprotein cholesterol. CVD was defined as myocardial infarction and stroke. Multivariate logistic regression and Cox regression models were used to evaluate the association between RC and MetS as well as CVD. We further investigated whether the association between RC and CVD was mediated by MetS.ResultsOf all subjects, 24.73% were diagnosed with MetS and 2.74% developed CVD. Multivariate logistic regression analysis elucidated that per-tertile-increase in RC was associated with MetS after adjusting all the confounder factors, (odds ratio: 3.49, 95% confidence interval CI 3.21–3.79, P for trend < 0.001). And per-tertile-increase RC had a significant increased risk of CVD (hazard ratio: 1.26, 95% CI 1.06–1.50, P for trend = 0.008). Meanwhile, we found that RC level is associated with the prevalence of all the components of MetS. Significant indirect effects of RC between MetS and CVD were found, with the index mediated at 48.46% of the association.ConclusionsOur study provides the evidence that RC level is independently associated with the prevalence of MetS and each component of MetS. MetS partially mediated the association between RC level and CVD risk.

【 授权许可】

CC BY   
© BioMed Central Ltd., part of Springer Nature 2023

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