Trends in genital warts by socioeconomic status after the introduction of the national HPV vaccination program in Australia: analysis of national hospital data

BMC Infectious Diseases

Research Article

Peter McIntyre¹  Aditi Dey¹  Robert Menzies²  Bette Liu³  Karen Canfell⁴  Megan A. Smith⁴ 

[1] National Centre for Immunisation Research and Surveillance Children’s Hospital, Westmead, Locked Mail Bag 4001, 2145, Sydney, NSW, Australia;National Centre for Immunisation Research and Surveillance Children’s Hospital, Westmead, Locked Mail Bag 4001, 2145, Sydney, NSW, Australia;Sydney Medical School, University of Sydney, 2006, Sydney, NSW, Australia;Present address: School of Public Health and Community Medicine, UNSW Australia, 2052, Sydney, NSW, Australia;School of Public Health and Community Medicine, UNSW Australia, 2052, Sydney, NSW, Australia;The Sax Institute, Sydney, PO Box K617, 1240, Haymarket, NSW, Australia;School of Public Health, University of Sydney, 2006, Sydney, NSW, Australia;Prince of Wales Clinical School, UNSW Australia, 2052, Sydney, NSW, Australia;Present address: Cancer Research Division, Cancer Council NSW, PO Box 572, Kings Cross NSW 1340, 2011, Sydney, NSW, Australia;

关键词: Human papillomavirus;    HPV;    Vaccination;    Genital warts;    Impact;    Socioeconomic;    SES;    Remoteness;    Geographic;    Immunization;   

DOI  :  10.1186/s12879-016-1347-z

 received in 2015-06-03, accepted in 2016-01-13,  发布年份 2016

来源: Springer

【 摘 要 】

BackgroundHuman papillomavirus (HPV) vaccination targeting females 12–13 years commenced in Australia in 2007, with catch-up of females 13–26 years until the end of 2009. No analyses of HPV vaccination program impact by either socioeconomic or geographic factors have been reported for Australia.MethodsHospital admissions between July 2004-June 2011 involving a diagnosis of genital warts were obtained from a comprehensive national database. We compared sex- and age-specific admission rates in July 2006–June 2007 (pre-vaccination period) and July 2010–June 2011 (post-vaccination period) according to Index of Relative Socio-economic Disadvantage, nationally and stratified by remoteness area relating to the individual’s area of residence, using Poisson/ negative binomial models.ResultsAdmission rates per 100,000 population in females aged 10–19 years (predominantly vaccinated at school), reduced from 42.2 to 6.0 (rate reduction 86.7 %; 95 % CI:82.2–90.0 %) in more disadvantaged areas and from 26.8 to 4.0 (85.0 %; 95 % CI:79.7–88.9 %) in less disadvantaged areas. In females aged 20–29 years (predominantly vaccinated in the community), the decreases were from 73.9 to 26.4 (66.0 %; 95 % CI:57.7–72.6 %) and from 61.9 to 23.8 (61.6 %; 95 % CI:52.9–68.7 %) in more and less disadvantaged areas, respectively. The reductions were similar in more vs less disadvantaged areas both inside major cities (88.6 %; 95 % CI: 82.2–92.7 % vs 87.9 %; 95 % CI:82.6–91.6 % in females aged 10–19 years; 64.0 %; 95 % CI:57.0–69.9 % vs 63.8 %; 95 % CI:52.9–72.1 % for females aged 20–29 years) and outside major cities (88.8 %; 95 % CI: 83.7–92.3 % vs 85.8 %; 95 % CI:73.5–92.4 % in females aged 10–19 years; 71.1 %; 95 % CI:58.8–79.7 % vs 67.6 %; 95 % CI:48.2–79.8 % for females aged 20–29 years). Admission rates in males aged 20–29 years also reduced, by 23.0 % (95 % CI:4.8–37.8 %) and 39.4 % (95 % CI:28.9–48.3 %) in more versus less disadvantaged areas respectively.ConclusionsThe relative reduction in genital warts appears similar in young females across different levels of disadvantage, including within and outside major cities, both for females predominantly vaccinated at school and in the community.

【 授权许可】

CC BY   
© Smith et al. 2016