Estimating the survival advantage based on telomere length and serum biomarkers of aging

Journal of Translational Medicine

Research

Shijun Li¹  Hui Liu¹  Yilin Zhao¹ 

[1] College of Medical Laboratory, Dalian Medical University, 116044, Dalian, China;

关键词: Aging;    Albumin;    Telomere length;    Survival advantage;   

DOI  :  10.1186/s12967-017-1267-8

 received in 2017-05-16, accepted in 2017-07-19,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundThis study aimed to establish a model that estimates the survival advantage at the molecular level based on telomere length and serum biomarkers of aging, to explore clinical significance.MethodsThe study consisted of 100 healthy subjects and 40 type 2 diabetes mellitus patients, 20–90 years of age. Saliva telomere relative length (LnTL) was measured by the quantitative real-time polymerase chain reaction and the serum biochemical parameters, including albumin (ALB), total proteins, total cholesterol, triglycerides, and some enzyme parameters were detected by a biochemical analyzer. The Z values were transformed from mean values and standard deviations to estimate the survival advantage. A normal reference range (95% confidence interval) was set to the comprehensive advantage of the Z values (Zs) to evaluate the comprehensive survival advantage.ResultsThe Z values of serum ALB and saliva LnTL could be used to estimate the survival advantage, and effectively distinguish between the aging and nonaging individuals. The Zs was greater than 1.64 in the normal reference range, and type 2 diabetes mellitus patients had lower survival advantages compared to those of the control group (p < 0.05).ConclusionsOur two-dimensional model system using ALB and LnTL was valid and may have potential applications for evaluating the aging status at the molecular level, and for the observation of disease characteristics.

【 授权许可】

CC BY   
© The Author(s) 2017

【 图 表 】

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