Mitochondrial transfer in hematological malignancies

Biomarker Research

Review

Yihong Wei¹  Hanyang Wu¹  Xinyu Yang¹  Jinting Liu¹  Hexiao Jia¹  Wancheng Liu¹  Wenbo Jia¹  Xiaodong Guo¹  Can Can¹  Daoxin Ma¹ 

[1] Department of Hematology, Qilu Hospital of Shandong University, 250012, Jinan, Shandong, P.R. China;

关键词: Mitochondrial transfer;    Tunneling nanotubes;    Extracellular vesicles;    Extracellular mitochondria;    Hematological malignancies;   

DOI  :  10.1186/s40364-023-00529-x

 received in 2023-05-24, accepted in 2023-09-24,  发布年份 2023

来源: Springer

【 摘 要 】

Mitochondria are energy-generated organelles and take an important part in biological metabolism. Mitochondria could be transferred between cells, which serves as a new intercellular communication. Mitochondrial transfer improves mitochondrial defects, restores the biological functions of recipient cells, and maintains the high metabolic requirements of tumor cells as well as drug resistance. In recent years, it has been reported mitochondrial transfer between cells of bone marrow microenvironment and hematological malignant cells play a critical role in the disease progression and resistance during chemotherapy. In this review, we discuss the patterns and mechanisms on mitochondrial transfer and their engagement in different pathophysiological contexts and outline the latest knowledge on intercellular transport of mitochondria in hematological malignancies. Besides, we briefly outline the drug resistance mechanisms caused by mitochondrial transfer in cells during chemotherapy. Our review demonstrates a theoretical basis for mitochondrial transfer as a prospective therapeutic target to increase the treatment efficiency in hematological malignancies and improve the prognosis of patients.

【 授权许可】

CC BY   
© Yumed Inc. and BioMed Central Ltd., part of Springer Nature 2023

【 图 表 】

Fig. 2

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