Oral hyaluronan relieves knee pain: a review

Nutrition Journal

Review

Naoshi Fukui¹  Koh Maruyama²  Hiroshi Nishiyama³  Yasunobu Masuda³  Hideto Yoshida³  Mariko Oe³  Reiko Maruya⁴  Takashi Koikeda⁵  Toshiyuki Tashiro⁶ 

[1] Department of Life Science, Graduate School of Arts and Sciences, The University of Tokyo, 3-8-1 Komaba, Meguro-ku, Tokyo, Japan;Gate Town Hospital, 1-6-19, Sekimachi-kita, Nerima-ku, Tokyo, Japan;R&D Division, Kewpie Corporation, 2-5-7, Sengawa-cho, Chofu-shi, Tokyo, Japan;SOUKEN Corporation, 1-9-10, Hamamatsu-cho, Minato-ku, Tokyo, Japan;Shiba Palace Clinic, 1-9-10 Hamamatsucho, Minato-ku, Tokyo, Japan;Tokyo Yamate Medical Center, 3-22-1 Hyakunin-cho, Shinjyuku-ku, Tokyo, Japan;

关键词: Hyaluronan;    Hyaluronic acid;    Dietary supplement;    Knee;    Joint;    Osteoarthritis;   

DOI  :  10.1186/s12937-016-0128-2

 received in 2015-11-09, accepted in 2016-01-19,  发布年份 2016

来源: Springer

【 摘 要 】

Hyaluronan (HA) is a component that is particularly abundant in the synovial fluid. Randomized, double-blinded, placebo-controlled trials carried out between 2008 and 2015 have proven the effectiveness of HA for the treatment of symptoms associated with synovitis, and particularly, knee pain, relief of synovial effusion or inflammation, and improvement of muscular knee strength. The mechanism by which HA exerts its effects in the living body, specifically receptor binding in the intestinal epithelia, has gradually been clarified. This review examines the effects of HA upon knee pain as assessed in clinical trials, as well as the mechanism of these effects and the safety of HA.

【 授权许可】

CC BY   
© Oe et al. 2016