Plasma metabolomics profiles in Black and White participants of the Adventist Health Study-2 cohort

BMC Medicine

Research Article

Jason Utt¹  Gary E. Fraser²  Fayth M. Butler³  Carlos A. Casiano⁴  Suzanne Montgomery⁵  Seth A. Wiafe⁶  Roy O. Mathew⁷  Johanna W. Lampe⁸ 

[1] Adventist Health Study, Loma Linda University, Loma Linda, CA, USA;Adventist Health Study, Loma Linda University, Loma Linda, CA, USA;Center for Nutrition, Healthy Lifestyle, and Disease Prevention, School of Public Health, Loma Linda University, 24951 Circle Drive, NH2031, 92350, Loma Linda, CA, USA;Department of Medicine, School of Medicine, Loma Linda University, Loma Linda, CA, USA;Adventist Health Study, Loma Linda University, Loma Linda, CA, USA;Center for Nutrition, Healthy Lifestyle, and Disease Prevention, School of Public Health, Loma Linda University, 24951 Circle Drive, NH2031, 92350, Loma Linda, CA, USA;Department of Preventive Medicine, School of Medicine, Loma Linda University, Loma Linda, CA, USA;Center for Health Disparities and Molecular Medicine, Loma Linda University School of Medicine, Loma Linda, CA, USA;Department of Basic Science, Loma Linda University School of Medicine, Loma Linda, CA, USA;Center for Health Disparities and Molecular Medicine, Loma Linda University School of Medicine, Loma Linda, CA, USA;Department of Basic Science, Loma Linda University School of Medicine, Loma Linda, CA, USA;Center for Health Disparities and Molecular Medicine, Loma Linda University School of Medicine, Loma Linda, CA, USA;School of Behavioral Health, Loma Linda University, 92350, Loma Linda, CA, USA;Center for Leadership in Health Systems, School of Public Health, Loma Linda University, Loma Linda, CA, USA;Division of Nephrology, Department of Medicine, Loma Linda VA Health Care System, Loma Linda, CA, USA;Department of Medicine, School of Medicine, Loma Linda University, Loma Linda, CA, USA;Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA;

关键词: Metabolomics;    Cohort;    Dietary pattern;    Health disparities;    Black Americans;    Linear regression;    Cardiometabolic;    Lipids;    Creatine;   

DOI  :  10.1186/s12916-023-03101-4

 received in 2023-03-24, accepted in 2023-10-03,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundBlack Americans suffer disparities in risk for cardiometabolic and other chronic diseases. Findings from the Adventist Health Study-2 (AHS-2) cohort have shown associations of plant-based dietary patterns and healthy lifestyle factors with prevention of such diseases. Hence, it is likely that racial differences in metabolic profiles correlating with disparities in chronic diseases are explained largely by diet and lifestyle, besides social determinants of health.MethodsUntargeted plasma metabolomics screening was performed on plasma samples from 350 participants of the AHS-2, including 171 Black and 179 White participants, using ultrahigh-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) and a global platform of 892 metabolites. Differences in metabolites or biochemical subclasses by race were analyzed using linear regression, considering various models adjusted for known confounders, dietary and/or other lifestyle behaviors, social vulnerability, and psychosocial stress. The Storey permutation approach was used to adjust for false discovery at FDR < 0.05.ResultsLinear regression revealed differential abundance of over 40% of individual metabolites or biochemical subclasses when comparing Black with White participants after adjustment for false discovery (FDR < 0.05), with the vast majority showing lower abundance in Blacks. Associations were not appreciably altered with adjustment for dietary patterns and socioeconomic or psychosocial stress. Metabolite subclasses showing consistently lower abundance in Black participants included various lipids, such as lysophospholipids, phosphatidylethanolamines, monoacylglycerols, diacylglycerols, and long-chain monounsaturated fatty acids, among other subclasses or lipid categories. Among all biochemical subclasses, creatine metabolism exclusively showed higher abundance in Black participants, although among metabolites within this subclass, only creatine showed differential abundance after adjustment for glomerular filtration rate. Notable metabolites in higher abundance in Black participants included methyl and propyl paraben sulfates, piperine metabolites, and a considerable proportion of acetylated amino acids, including many previously found associated with glomerular filtration rate.ConclusionsDifferences in metabolic profiles were evident when comparing Black and White participants of the AHS-2 cohort. These differences are likely attributed in part to dietary behaviors not adequately explained by dietary pattern covariates, besides other environmental or genetic factors. Alterations in these metabolites and associated subclasses may have implications for the prevention of chronic diseases in Black Americans.

【 授权许可】

CC BY   
© The Author(s) 2023

【 图 表 】

Fig. 4