The physiological and pathological properties of Mead acid, an endogenous multifunctional n-9 polyunsaturated fatty acid

Lipids in Health and Disease

Review

Katsuhiko Yoshizawa¹  Hiroshi Kawashima² 

[1] Department of Innovative Food Sciences, School of Food Sciences and Nutrition, Mukogawa Womenʼs University, Nishinomiya, Hyogo, Japan;Research Institute, Suntory Global Innovation Center Ltd, Seika, Kyoto, Japan;

关键词: Mead acid;    Eicosatrienoic acid;    n-9;    Arachidonic acid;    Essential fatty acid;    Polyunsaturated fatty acid;   

DOI  :  10.1186/s12944-023-01937-6

 received in 2023-08-17, accepted in 2023-10-08,  发布年份 2023

来源: Springer

【 摘 要 】

Mead acid (MA, 5,8,11-eicosatrienoic acid) is an n-9 polyunsaturated fatty acid (PUFA) and a marker of essential fatty acid deficiency, but nonetheless generally draws little attention. MA is distributed in various normal tissues and can be converted to several specific lipid mediators by lipoxygenase and cyclooxygenase. Recent pathological and epidemiological studies on MA raise the possibility of its effects on inflammation, cancer, dermatitis and cystic fibrosis, suggesting it is an endogenous multifunctional PUFA. This review summarizes the biosynthesis, presence, metabolism and physiological roles of MA and its relation to various diseases, as well as the significance of MA in PUFA metabolism.

【 授权许可】

CC BY   
© BioMed Central Ltd., part of Springer Nature 2023

【 图 表 】

Fig. 6

Fig. 1