期刊论文详细信息
Journal of Biomedical Science
Differential effects of taurine treatment and taurine deficiency on the outcome of renal ischemia reperfusion injury
Review
Mahmood S Mozaffari1  Champa Patel1  Hereward Wimborne1  Jun Yao Liu1  Rafik Abdelsayed2  Stephen W Schaffer3 
[1] Department of Oral Biology, Medical College of Georgia School of Dentistry, 30912, Augusta, Georgia, USA;Department of Oral Health and Diagnostic Sciences, Medical College of Georgia School of Dentistry, 30912, Augusta, Georgia, USA;Department of Pharmacology, University of South Alabama Mobile, 36688, Alabama, USA;
关键词: Taurine;    Ischemia Reperfusion;    Sham Control;    Urine Osmolality;    Regulatory Volume Decrease;   
DOI  :  10.1186/1423-0127-17-S1-S32
来源: Springer
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【 摘 要 】

Taurine possesses membrane stabilization, osmoregulatory and antioxidant properties, aspects of relevance to ischemic injury. We tested the hypothesis that body taurine status is a determinant of renal ischemic injury. Accordingly, renal function and structure were examined in control (C), taurine-treated (TT) and taurine deficient (TD) rats that were subjected to bilateral renal ischemia (60 min) followed by reperfusion (IR); sham operated rats served as controls. Baseline urine osmolality was greater in the TD group than in the control and the TT groups, an effect associated with increased renal aquaporin 2 level. The IR insult reduced urine osmolality (i.e., day-1 post insult); the TD/IR group displayed a more marked recovery in urine osmolality by day-6 post insult than the other two groups. Fluid and sodium excretions were lower in the TD/IR group, suggesting propensity to retention. Histopathological examination revealed the presence of tubular necrotic foci in the C/IR group than sham controls. While renal architecture of the TD/IR group showed features resembling sham controls, the TT/IR group showed dilated tubules, which lacked immunostaining for aquaporin 2, but not 1, suggestive of proximal tubule origin. Finally, assessment of cell proliferation and apoptosis revealed lower proliferation but higher apoptotic foci in the TT/IR group than other IR groups. Collectively, the results indicate that body taurine status is a major determinant of renal IR injury.

【 授权许可】

CC BY   
© Mozaffari et al; licensee BioMed Central Ltd. 2010

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