Acetic acid-indigo carmine chromoendoscopy for delineating early gastric cancers: its usefulness according to histological type

BMC Gastroenterology

Research Article

Hyun Seok You¹  Geun Am Song¹  Dong Uk Kim¹  Su Bum Park¹  Dong Yup Ryu¹  Bong Eun Lee¹  Gwang Ha Kim¹  Do Youn Park²  Dae Hwan Kim³  Tae Yong Jeon³ 

[1] Department of Internal Medicine, Pusan National University School of Medicine and Medical Research Institute, Pusan National University Hospital, Busan, Korea;Department of Pathology, Pusan National University School of Medicine, Busan, Korea;Department of Surgery, Pusan National University School of Medicine, Busan, Korea;

关键词: Diagnostic Performance;    Endoscopic Submucosal Dissection;    Early Gastric Cancer;    Endoscopic Resection;    Laparoscopic Gastrectomy;   

DOI  :  10.1186/1471-230X-10-97

 received in 2009-09-04, accepted in 2010-08-23,  发布年份 2010

来源: Springer

【 摘 要 】

BackgroundEndoscopic treatments, such as endoscopic submucosal dissection (ESD) and laparoscopic gastrectomy, are increasingly used to treat a subset of patients with early gastric cancer (EGC). To achieve successful outcomes, it is very important to accurately determine the lateral extent of the tumor. Therefore, we investigated the diagnostic performance of chromoendoscopy using indigo carmine dye added to acetic acid (AI chromoendoscopy) in delineating differentiated or undifferentiated adenocarcinomas in patients with EGC.MethodsWe prospectively included 151 lesions of 141 patients that had an endoscopic diagnosis of EGC. All the lesions were examined by conventional endoscopy and AI chromoendoscopy before ESD or laparoscopic gastrectomy. The border clarification between the lesion and the normal mucosa was classified as distinct or indistinct before and after AI chromoendoscopy.ResultsThe borders of the lesions were distinct in 66.9% (101/151) with conventional endoscopy and in 84.1% (127/151) with AI chromoendoscopy (P < 0.001). Compared with conventional endoscopy, AI chromoendoscopy clarified the border in a significantly higher percentage of differentiated adenocarcinomas (74/108 [68.5%] vs 97/108 [89.8%], respectively, P < 0.001). However, the border clarification rate for undifferentiated adenocarcinomas did not differ between conventional endoscopy and AI chromoendoscopy (27/43 [62.8%] vs 30/43 [70.0%], respectively, P = 0.494).ConclusionsAI chromoendoscopy is useful in determining the lateral extent of EGCs. However, its usefulness is reduced in undifferentiated adenocarcinomas.

【 授权许可】

Unknown   
© Lee et al; licensee BioMed Central Ltd. 2010. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.