Plasma trans-fatty acids levels and mortality: a cohort study based on 1999–2000 National Health and Nutrition Examination Survey (NHANES)

Lipids in Health and Disease

Research

Qian Zhang¹  Yunfei Zou²  Anshi Wang²  Yufeng Wen²  Jiangen Song²  Lei Ding²  Haibo Li³ 

[1] Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 230032, Hefei, China;School of Public Health, Wannan Medical College, No. 22 Western Wenchang Road, 241002, Wuhu, China;School of Public Health, Wannan Medical College, No. 22 Western Wenchang Road, 241002, Wuhu, China;Graduate School, Peking Union Medical College, 100730, Beijing, China;Department of Epidemiology, Capital Institute of Pediatrics, 100020, Beijing, China;

关键词: Trans-fatty acids;    Mortality;    Cardiovascular diseases;    Cancer;   

DOI  :  10.1186/s12944-017-0567-6

 received in 2017-08-10, accepted in 2017-09-11,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundTrans-fatty acids (TFAs) occur in small amounts in nature but became widely produced by the food industry. The hazardous effects of different TFA subtypes to human health are controversial. We aimed to evaluate the association of plasma TFAs levels (elaidic acid, vaccenic acid, palmitelaidic acid, and linoelaidic acid) with mortality.MethodsUtilizing 1999–2000 Nutrition Examination Survey (NHANES) and linked mortality data, we performed a cohort study with 1456 participants and used Cox proportional hazards models and penalized smoothing spline plots to elucidate the relationships between TFAs and all-cause, cardiovascular diseases (CVD) and cancer mortality.ResultsDuring 16,034 person-years of follow-up, a total of 221 deaths occurred. In the multivariate model, including mutual adjustment for the 4 TFA subtypes, elaidic acid associated with higher all-cause mortality (hazard ratio (HR) = 2.00, 95% confidence interval (CI) = 1.18 to 3.40, fourth quartiles versus second quartiles) and CVD mortality (HR = 1.64, 95% CI = 1.07 to 2.50, per 10 units increase). Higher palmitelaidic acid levels were associated with increased cancer mortality (HR = 2.91, 95% CI = 1.09 to 7.81, fourth quartiles versus second quartiles). A J-shaped pattern was observed in the regression curve of elaidic acid and all-cause mortality, as well palmitelaidic acid and cancer mortality.ConclusionsPlasma elaidic acid levels are associated with higher risk of all-cause and CVD mortality, and palmitelaidic acid levels are associated with higher cancer mortality in later life. Further studies are needed to investigate current inconsistent results in this field and the possible underlying mechanisms.

【 授权许可】

CC BY   
© The Author(s). 2017